Center for Cancer Biology Research

癌症生物学研究中心

• 批准号: 10628878
• 负责人: W KEITH MISKIMINS
• 金额: $ 124.5万
• 依托单位: SANFORD RESEARCH/USD
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628878
• 关键词: Applications Grants; Award; Back; Basic Cancer Research; Cancer Biology; Cancer Center; Cancer Patient; Centers of Research Excellence; Communities; Core Facility; Data; Extramural Activities; Faculty; Fee-for-Service Plans; Funding; Funding Agency; Funding Mechanisms; Goals; Grant; Infrastructure; Institution; Journals; Manuscripts; Midwestern United States; Mission; Paper; Peer Review; Phase; Physicians; Principal Investigator; Publications; Publishing; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Schedule; Science; Scientist; Seasons; Secure; Services; Sioux Falls; Source; Study Section; Teacher Professional Development; Testing; Time; Translational Research; United States National Institutes of Health; anticancer research; editorial; expectation; improved; innovation; member; programs; recruit; research and development; success; translational cancer research; voucher

This CoBRE Phase III application aims to continue support for the Center for Cancer Biology Research (CCBR) which has established a strong research program within Sanford Research, Sioux Falls, SD. The original mission of the CCBR was to establish and grow cancer research with a focus on basic and translational activities. During Phase I CoBRE funding, the CCBR was established with five Project Leaders. Importantly, critical infrastructure, in the form of Scientific Cores, was developed and a Pilot Grant Program was initiated. The success of Phase I was marked by attainment of R01 level funding by Project Leaders who graduated from CoBRE funding and remain successful to this day. In addition, Project Leaders published important scientific papers in peer-reviewed journals and the Scientific Core functions began expanding as did their expertise. The power of the Pilot Grant program was demonstrated by scientific publications and obtaining of funding by awardees. These milestones enabled the awarding of CoBRE Phase II funding for the CCBR. While the missions of the CCBR remained unchanged, the influx of physician/scientists to the CCBR prompted an extensive focus on translational cancer research; a theme that remains strongly in place. Phase II Project Leaders were also successful in obtaining extramural funding and graduated from CoBRE support. Moreover, the Scientific Cores further expanded their services and began a more systematic approach (SmartSheets) to order, track and report back services to their users. In addition, fee-for-service schedules were developed for the Scientific Cores as they prepared for attaining self-sufficiency. The Pilot Grant program continued to provide funding to investigators who utilized these resources to successfully publish and obtain funding. Phase III CoBRE funding will enable the CCBR's Scientific Cores to reach a state of self-sustainability while continuing to offer critical services to CCBR members as well as non-CCBR members of Sanford Research and investigators from regional and national institutions. A critical component of this Phase III application will fund the CCBR's Pilot Grant Program. These Pilot Grants have proven to be essential sources of funding for new investigators and more seasoned faculty that want to test innovative hypotheses or require resources to generate data necessary to secure extramural funding. Historically, the CCBR's Pilot Grant Awardees have demonstrated that this funding results in peer-reviewed scientific publications and enables them to obtain funding from external sources. Moreover, a large percent of Pilot Grant projects utilizes the CCBR's Scientific Cores thereby contributing to their self-sustainability. The CCBR's successes over the past decade of CoBRE funding are a testament to the transformative power of this funding mechanism. Obtaining the final Phase of CoBRE funding will further strengthen the Scientific Cores, translational research, scientific culture of innovative science and the research infrastructure of the CCBR that began with Phase I CoBRE funding.

这项CoBRE第三阶段申请旨在继续支持癌症生物学研究中心 （CCBR），该研究所在南达科他州苏福尔斯的桑福德研究所内建立了一个强大的研究项目。的 CCBR的最初使命是建立和发展癌症研究，重点是基础和 翻译活动。在第一阶段的CoBRE资助期间，CCBR成立了五个项目负责人。 重要的是，以科学核心为形式的关键基础设施得到了开发， 被发起。第一阶段的成功标志着项目领导人获得了R 01级资金， 从Cobre基金毕业并成功至今。此外，项目负责人还出版了 在同行评审的期刊上发表重要的科学论文，科学核心的功能开始扩大， 他们的专业知识试点补助金计划的力量已经通过科学出版物和获得 由获奖者提供资金。这些里程碑使CCBR获得了CoBRE第二阶段的资助。 虽然CCBR的使命保持不变，但医生/科学家的涌入促使CCBR 广泛关注转化癌症研究;这是一个仍然存在的主题。二期工程 领导人还成功地获得了校外资金，并从Cobre的支持中毕业。此外，委员会认为， 科学核心进一步扩大了他们的服务，并开始采用更系统的方法（智能表）， 订购、跟踪和向用户报告服务。此外，还制定了服务收费表， 科学核心为实现自给自足做准备。试点补助金计划继续 向利用这些资源成功发表和获得资金的调查人员提供资金。相 III CoBRE资助将使CCBR的科学核心达到自我可持续的状态， 继续为桑福德研究中心的CCBR成员和非CCBR成员提供关键服务 以及区域和国家机构的调查员。第三阶段申请的一个关键组成部分将 资助CCBR的试点赠款计划。这些试点赠款已被证明是重要的资金来源， 新的研究人员和更有经验的教师想要测试创新的假设或需要资源， 生成必要的数据，以确保校外资金。从历史上看，CCBR的试点补助金获得者 表明，这笔资金导致同行评审的科学出版物，并使他们能够获得 外部资金来源。此外，很大一部分试点赠款项目利用了CCBR的科学 核心从而有助于其自我维持。CCBR在过去十年中的成功 这些资金证明了这一供资机制的变革力量。获得最后阶段的 CoBRE的资助将进一步加强科学核心，转化研究，科学文化， 创新科学和CCBR的研究基础设施始于第一阶段的CoBRE资金。