Center for Cancer Biology Research

癌症生物学研究中心

• 批准号: 10628878
• 负责人: W KEITH MISKIMINS
• 金额: $ 124.5万
• 依托单位: SANFORD RESEARCH/USD
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628878
• 关键词: Applications Grants; Award; Back; Basic Cancer Research; Cancer Biology; Cancer Center; Cancer Patient; Centers of Research Excellence; Communities; Core Facility; Data; Extramural Activities; Faculty; Fee-for-Service Plans; Funding; Funding Agency; Funding Mechanisms; Goals; Grant; Infrastructure; Institution; Journals; Manuscripts; Midwestern United States; Mission; Paper; Peer Review; Phase; Physicians; Principal Investigator; Publications; Publishing; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Schedule; Science; Scientist; Seasons; Secure; Services; Sioux Falls; Source; Study Section; Teacher Professional Development; Testing; Time; Translational Research; United States National Institutes of Health; anticancer research; editorial; expectation; improved; innovation; member; programs; recruit; research and development; success; translational cancer research; voucher

This CoBRE Phase III application aims to continue support for the Center for Cancer Biology Research (CCBR) which has established a strong research program within Sanford Research, Sioux Falls, SD. The original mission of the CCBR was to establish and grow cancer research with a focus on basic and translational activities. During Phase I CoBRE funding, the CCBR was established with five Project Leaders. Importantly, critical infrastructure, in the form of Scientific Cores, was developed and a Pilot Grant Program was initiated. The success of Phase I was marked by attainment of R01 level funding by Project Leaders who graduated from CoBRE funding and remain successful to this day. In addition, Project Leaders published important scientific papers in peer-reviewed journals and the Scientific Core functions began expanding as did their expertise. The power of the Pilot Grant program was demonstrated by scientific publications and obtaining of funding by awardees. These milestones enabled the awarding of CoBRE Phase II funding for the CCBR. While the missions of the CCBR remained unchanged, the influx of physician/scientists to the CCBR prompted an extensive focus on translational cancer research; a theme that remains strongly in place. Phase II Project Leaders were also successful in obtaining extramural funding and graduated from CoBRE support. Moreover, the Scientific Cores further expanded their services and began a more systematic approach (SmartSheets) to order, track and report back services to their users. In addition, fee-for-service schedules were developed for the Scientific Cores as they prepared for attaining self-sufficiency. The Pilot Grant program continued to provide funding to investigators who utilized these resources to successfully publish and obtain funding. Phase III CoBRE funding will enable the CCBR's Scientific Cores to reach a state of self-sustainability while continuing to offer critical services to CCBR members as well as non-CCBR members of Sanford Research and investigators from regional and national institutions. A critical component of this Phase III application will fund the CCBR's Pilot Grant Program. These Pilot Grants have proven to be essential sources of funding for new investigators and more seasoned faculty that want to test innovative hypotheses or require resources to generate data necessary to secure extramural funding. Historically, the CCBR's Pilot Grant Awardees have demonstrated that this funding results in peer-reviewed scientific publications and enables them to obtain funding from external sources. Moreover, a large percent of Pilot Grant projects utilizes the CCBR's Scientific Cores thereby contributing to their self-sustainability. The CCBR's successes over the past decade of CoBRE funding are a testament to the transformative power of this funding mechanism. Obtaining the final Phase of CoBRE funding will further strengthen the Scientific Cores, translational research, scientific culture of innovative science and the research infrastructure of the CCBR that began with Phase I CoBRE funding.

该 CoBRE III 期申请旨在继续支持癌症生物学研究中心 (CCBR) 在南达科他州苏福尔斯的桑福德研究中心建立了强大的研究项目。这 CCBR 的最初使命是建立和发展癌症研究，重点是基础和 翻译活动。在第一阶段 CoBRE 资助期间，CCBR 成立，有五名项目负责人。 重要的是，以科学核心的形式开发了关键基础设施，并制定了试点资助计划 被发起。第一阶段的成功标志是项目负责人获得了 R01 级资金， 从 CoBRE 资助毕业，至今仍保持成功。此外，项目负责人还发布了 同行评审期刊上的重要科学论文和科学核心功能也开始扩展 他们的专业知识。科学出版物和获得的成果证明了试点资助计划的力量 获奖者的资助。这些里程碑使 CCBR 能够获得 CoBRE 第二阶段资金。 虽然 CCBR 的使命保持不变，但医生/科学家的涌入 CCBR 促使 广泛关注转化癌症研究；这个主题仍然牢固地存在。二期工程 领导者还成功获得了外部资金并获得了 CoBRE 的支持。而且， 科学核心进一步扩大了他们的服务，并开始采用更系统的方法（SmartSheets） 向用户订购、跟踪和报告服务。此外，还制定了按服务收费的时间表 科学核心为实现自给自足做准备。试点补助金计划继续 为利用这些资源成功发表文章并获得资金的研究人员提供资金。阶段 III CoBRE 资金将使 CCBR 的科学核心达到自我维持的状态，同时 继续为 CCBR 成员以及 Sanford Research 的非 CCBR 成员提供关键服务 以及来自区域和国家机构的调查人员。该第三阶段应用的一个关键组成部分将 为 CCBR 试点拨款计划提供资金。事实证明，这些试点补助金是重要的资金来源 新的研究人员和经验丰富的教师想要测试创新假设或需要资源 生成获得外部资金所需的数据。从历史上看，CCBR 试点拨款获得者曾 证明这笔资金会产生经过同行评审的科学出版物，并使他们能够获得 来自外部来源的资金。此外，很大一部分试点拨款项目都利用了 CCBR 的科学技术 核心因此有助于其自我维持。 CCBR 在 CoBRE 过去十年中取得的成功 资金证明了这一筹资机制的变革力量。获得最终阶段 CoBRE 资助将进一步加强科学核心、转化研究和科学文化 CCBR 的创新科学和研究基础设施始于第一阶段 CoBRE 资助。