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Center for Cancer Biology Research

癌症生物学研究中心

基本信息

批准号：
10628878
负责人：
W KEITH MISKIMINS
金额：
$ 124.5万
依托单位：
SANFORD RESEARCH/USD
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628878
关键词：
Applications Grants Award Back Basic Cancer Research Cancer Biology Cancer Center Cancer Patient Centers of Research Excellence Communities Core Facility Data Extramural Activities Faculty Fee-for-Service Plans Funding Funding Agency Funding Mechanisms Goals Grant Infrastructure Institution Journals Manuscripts Midwestern United States Mission Paper Peer Review Phase Physicians Principal Investigator Publications Publishing Reporting Research Research Infrastructure Research Personnel Research Support Resources Schedule Science Scientist Seasons Secure Services Sioux Falls Source Study Section Teacher Professional Development Testing Time Translational Research United States National Institutes of Health anticancer research editorial expectation improved innovation member programs recruit research and development success translational cancer research voucher

项目摘要

This CoBRE Phase III application aims to continue support for the Center for Cancer Biology Research (CCBR) which has established a strong research program within Sanford Research, Sioux Falls, SD. The original mission of the CCBR was to establish and grow cancer research with a focus on basic and translational activities. During Phase I CoBRE funding, the CCBR was established with five Project Leaders. Importantly, critical infrastructure, in the form of Scientific Cores, was developed and a Pilot Grant Program was initiated. The success of Phase I was marked by attainment of R01 level funding by Project Leaders who graduated from CoBRE funding and remain successful to this day. In addition, Project Leaders published important scientific papers in peer-reviewed journals and the Scientific Core functions began expanding as did their expertise. The power of the Pilot Grant program was demonstrated by scientific publications and obtaining of funding by awardees. These milestones enabled the awarding of CoBRE Phase II funding for the CCBR. While the missions of the CCBR remained unchanged, the influx of physician/scientists to the CCBR prompted an extensive focus on translational cancer research; a theme that remains strongly in place. Phase II Project Leaders were also successful in obtaining extramural funding and graduated from CoBRE support. Moreover, the Scientific Cores further expanded their services and began a more systematic approach (SmartSheets) to order, track and report back services to their users. In addition, fee-for-service schedules were developed for the Scientific Cores as they prepared for attaining self-sufficiency. The Pilot Grant program continued to provide funding to investigators who utilized these resources to successfully publish and obtain funding. Phase III CoBRE funding will enable the CCBR's Scientific Cores to reach a state of self-sustainability while continuing to offer critical services to CCBR members as well as non-CCBR members of Sanford Research and investigators from regional and national institutions. A critical component of this Phase III application will fund the CCBR's Pilot Grant Program. These Pilot Grants have proven to be essential sources of funding for new investigators and more seasoned faculty that want to test innovative hypotheses or require resources to generate data necessary to secure extramural funding. Historically, the CCBR's Pilot Grant Awardees have demonstrated that this funding results in peer-reviewed scientific publications and enables them to obtain funding from external sources. Moreover, a large percent of Pilot Grant projects utilizes the CCBR's Scientific Cores thereby contributing to their self-sustainability. The CCBR's successes over the past decade of CoBRE funding are a testament to the transformative power of this funding mechanism. Obtaining the final Phase of CoBRE funding will further strengthen the Scientific Cores, translational research, scientific culture of innovative science and the research infrastructure of the CCBR that began with Phase I CoBRE funding.

这项CoBRE III期申请旨在继续支持癌症生物学研究中心