T32 Training Program in Cancer Biology

T32 癌症生物学培训计划

• 批准号: 10714463
• 负责人: David Sung-wen Yu
• 金额: $ 16.63万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714463
• 关键词: Cancer Biology; Training Programs

PROJECT SUMMARY Advances in our understanding of the biology of cancer have the potential to lead to significant breakthroughs in cancer diagnosis and treatment; however, the translation of basic science discoveries to clinical advancement has been impaired by the dichotomous training of basic scientists and clinicians. Thus, there is a compelling need for an enhanced mentored research training program that will bridge the gap between training in rigorous scientific investigation following the scientific method and compassionate clinical care for the patient. We propose a Training Program in Cancer Biology that will take advantage of the outstanding resources, high caliber of investigators, and close collaboration between cancer biologists and clinicians at the Winship Cancer Institute of Emory University, Georgia’s first and only NCI-designated comprehensive cancer center, to provide a unique, individualized, and multi-faceted training experience to support the development of postdoctoral trainees in acquiring the knowledge and skills to address the most important biological questions and clinically significant problems so that they can make transformative discoveries to improve quality of care for patients with cancer. The objective of the Emory Training Program in Cancer Biology is to provide postdoctoral trainees with the infrastructure, resources, training, experience, and mentorship to acquire the depth of knowledge and critical skills in cancer biology research combined with the practical exposure and understanding of clinical concepts to initiate an impactful independent research program that will translate novel insights in cancer biology into improvements in clinical care. Aims of the training program include: 1) Organized research training, 2) Comprehensive formal and informal didactics, 3) Clinical exposure through tumor boards and clinics, 4) Career development activities, and 5) Plan for transition to independence. The program will train two new postdoctoral trainees in the first year followed by an additional two trainees in the second year for a total of four trainees per year by the second year. Postdoctoral trainees will be rigorously selected from an exceptionally strong and broad applicant pool of PhD and/or MDs within the first two years of their postdoctoral training and will complete 12-24 months of full-time mentored research. Trainees will have the opportunity to engage in independent research in the labs of a multidisciplinary group of 22 well-funded and experienced Mentors and junior Mentors paired with a senior co-Mentor from 10 basic science and clinical departments who are all full members of three complementary and synergistic research programs of the Winship Cancer Institute: 1) Cell and Molecular Biology, 2) Cancer Immunology, and 3) Discovery and Developmental Therapeutics. All trainees will be required to form a Mentoring Committee with at least one clinical mentor. Outstanding institutional commitment and focus on inclusive excellence includes support for an additional postdoctoral trainee position per year for the recruitment of an underrepresented trainee, salary support for the PI, administrators, and trainees, and Office of Postdoctoral Education resources. This program intends to train the next generation of cancer scientific leaders.

项目摘要 我们对癌症生物学的理解的进步有可能导致重大突破， 癌症诊断和治疗;然而，基础科学发现转化为临床进步 已经被基础科学家和临床医生的二分训练所削弱。因此， 需要一个加强的指导研究培训计划，将弥合培训之间的差距严格 遵循科学方法的科学调查和对患者的富有同情心的临床护理。我们提出 在癌症生物学的培训计划，将利用优秀的资源，高素质的 研究人员，以及癌症生物学家和临床医生之间的密切合作，在温希普癌症研究所， 埃默里大学，格鲁吉亚第一个也是唯一一个NCI指定的综合性癌症中心，提供一个独特的， 个性化，多方面的培训经验，以支持博士后学员的发展， 获得知识和技能，以解决最重要的生物学问题和临床意义 这样他们就可以做出变革性的发现，以提高癌症患者的护理质量。 埃默里癌症生物学培训计划的目标是为博士后学员提供 基础设施，资源，培训，经验和指导，以获得知识的深度和关键 在癌症生物学研究的技能结合实际接触和临床概念的理解， 启动一项有影响力的独立研究计划，将癌症生物学的新见解转化为 改善临床护理。培训计划的目的包括：1）有组织的研究培训，2） 全面的正式和非正式教学，3）通过肿瘤委员会和诊所的临床接触，4）职业生涯 发展活动; 5）向独立过渡的计划。该计划将培养两名新的博士后 第一年增加两名受训人员，第二年增加两名受训人员， 第二年。博士后培训生将严格从一个非常强大和广泛的选择 申请人池博士和/或医学博士在他们的博士后培训的头两年，并将完成12-24 几个月的全职研究。学员将有机会从事独立研究， 一个由22名资金充足、经验丰富的导师和初级导师组成的多学科小组的实验室， 来自10个基础科学和临床部门的高级共同导师，他们都是三个部门的正式成员。 温希普癌症研究所的互补和协同研究计划：1）细胞和分子生物学， 2)癌症免疫学，和3）发现和发展治疗。所有学员都必须 指导委员会，至少有一名临床指导员。突出的机构承诺和重点 包容性卓越包括每年为招聘额外的博士后实习生职位提供支持 代表性不足的培训生，PI，管理人员和培训生的工资支持，以及博士后办公室 教育资源该计划旨在培养下一代癌症科学领导者。

项目成果

Impact of immunotherapy time-of-day infusion on survival and immunologic correlates in patients with metastatic renal cell carcinoma: a multicenter cohort analysis.

免疫治疗每日输注时间对转移性肾细胞癌患者生存和免疫相关性的影响：多中心队列分析。

• DOI: 10.1136/jitc-2023-008011
• 发表时间: 2024
• 期刊: Journal for immunotherapy of cancer
• 影响因子: 10.9
• 作者: Patel,JimmyS;Woo,Yena;Draper,Amber;Jansen,CarolineS;Carlisle,JenniferW;Innominato,PasqualeF;Lévi,FrancisA;Dhabaan,Layla;Master,VirajA;Bilen,MehmetA;Khan,MohammadK;Lowe,MichaelC;Kissick,Haydn;Buchwald,ZacharyS;Qian,Da
• 通讯作者: Qian,Da