Conserved Transcriptional Response to Adversity (CTRA) and COVID-19: Role of Pre-existing Neighborhood Characteristics and Cognitive Impairment

贝特曼等人，NOT-AG-20-022 2020 项目总结 拟议的行政补编将用于调查新冠肺炎对以下活动参与者的影响 维克森林阿尔茨海默病研究中心(ADRC)。我们将确定新冠肺炎的影响 与老年人相比，认知障碍患者的相关社交距离和压力 WF ADRC中心队列中的正常认知。拟议的补充将在临床上进行 维克森林医学院ADRC的核心队列，属于ADRC的一般范围 找出调节衰老和阿尔茨海默病认知衰退的因素，并与我们的 中心通过利用社区劣势的衡量标准来关注健康差距。该提案的基础是 有证据表明，孤独和压力与认知能力下降有关，预计 因社会疏远流行的公共卫生措施，防止新冠肺炎传播。 先前的几项研究表明，孤独与老年人的慢性压力有关，而且 孤独与认知能力下降有更深一步的联系，这可能是一种双向关系。 孤独感也被证明受到邻居变量的影响。我们建议的补充部分将 考察新冠肺炎对孤独感和压力的影响，并确定参与者是否有预 大流行认知障碍，或那些生活在更贫穷的社区的人，更容易受到 冲击力。我们建议的研究包括两个部分：电话问卷访问和血迹干点 用于转录分析的集合。我们将收集两份关于COVID-19影响的问卷， 以及评估感受到的压力、孤独、应对策略和心理健康的问卷- 是存在的。每个参与者都将被地理编码，他们的区域剥夺指数将基于公共- 可用的数据。与加州大学洛杉矶分校社会基因组核心建立了新的合作关系 它将执行RNA提取和分析。 1

Bateman et al., NOT-AG-20-022 2020 PROJECT SUMMARY The proposed administrative supplement will fund an investigation of the impact of COVID-19 on participants of the Wake Forest Alzheimer’s Disease Research Center (ADRC). We will determine the impact of COVID-19 related social distancing and stress on individuals with cognitive impairment as compared to older adults with normal cognition in the WF ADRC center cohort. The proposed supplement will be conducted in the Clinical Core cohort of the ADRC at Wake Forest School of Medicine, and falls within the general scope of the ADRC of identifying factors that modulate cognitive decline in aging and Alzheimer’s disease, and synergizes with our center’s focus on health disparities by utilizing a metric of neighborhood disadvantage. The proposal is based on evidence that loneliness and stress are associated with cognitive decline and are expected to be more prevalent as a result of social distancing public health measures for the prevention of COVID-19 spread. Several prior studies have shown that loneliness is associated with chronic stress in older adults, and that loneliness is further associated with cognitive decline, with some suggestion of a bidirectional relationship. Loneliness has been shown to be affected by neighborhood variables as well. Our proposed supplement will examine the impact of COVID-19 on loneliness and stress, and determine whether participants with pre- pandemic cognitive impairment, or those living in more deprived neighborhoods, are more vulnerable to the impact. There are two parts to our proposed study: a telephone-based questionnaire visit and dried blood spot collection for transcriptional analysis. We will collected two questionnaires focused on the impact of COVID-19, as well as questionnaires to assess perceived stress, loneliness, coping strategies, and psychological well- being. Each participant will be geocoded and their area deprivation index will be obtained based on publically- available data. A new collaborative relationship has been established with the UCLA Social Genomics Core which will perform the RNA extraction and analysis. 1