P20 Exploratory Center for Precision Health in Diverse Populations

摘要/项目摘要 行政核心 本提案响应RFA-NR-10-002：NINR探索性中心（P20）。我们提出的总体目标是 NYU Meyers P20探索中心在不同人群中的精确健康是为了改善健康 通过解决生物多样性和共同的机制，症状，可改变的因素， 代谢综合征（MetS）和由此产生的2型糖尿病（T2 D）、心血管的不可改变因素 疾病（CVD）和相关的多种慢性疾病（MCC）同时发生，并使 诊断和治疗。我们将从精确的生态学角度来处理这项工作。一些最 实施这项工作的重大障碍在于确定如何最好地让不同社区参与 在科学和生物行为，组学，上下文，生活方式和家族因素的MetS和MCC牵连 以及如何最好地干预和降低风险。我们将在历史上不同的群体中进行这项研究， 在研究中代表性不足，包括种族/族裔少数、儿童、妇女、老年人和其他 弱势群体。其他特征，如性取向（LGBQ），性别认同（非顺式或 变性人）、残疾状况、宗教或精神信仰、社会经济地位不利的背景和原籍国 我们的研究也会考虑到这一点。该中心的行政核心是重点支持研究， 在真实的世界中应用精确的生态学方法解决这些问题 来改善公众健康。 行政核心将负责协调和监督科学和行政工作， 中心的活动，包括总体目标，内部和外部沟通，合规性， 评估和可持续性。我们将评估中心的生产力、有效性和适当性 活动;确定中心附属机构的标准，并促进整个纽约大学与研究人员的合作 研究代谢综合征、2型糖尿病、心血管疾病和相关慢性疾病。所有活动将与中心的总体目标保持一致 支持对生物多样性和共同机制、症状、可改变因素的研究， 作为MetS和相关MCC基础的不可改变的因素，以改善医疗保健结果并减少 健康差距。

Abstract/Project Summary ADMINISTRATIVE CORE This proposal responds to RFA-NR-10-002: NINR Exploratory Center (P20). The overall goal of our proposed NYU Meyers P20 Exploratory Center for Precision Health in Diverse Populations is to improve health outcomes by addressing biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors of metabolic syndrome (MetS) and resulting type 2 diabetes (T2D), cardiovascular disease (CVD), and related multiple chronic conditions (MCC) that occur simultaneously and complicate diagnosis and treatment. We will approach this work from a precision ecological perspective. Some of the most significant barriers to implementation of this work are in determining how best to engage diverse communities in the science and of biobehavioral, omic, contextual, lifestyle and familial factors implicated in MetS and MCC and how best to intervene and reduce risks. We will conduct this research in diverse groups that are historically under-represented in research, including racial/ethnic minorities, children, women, elderly, and other vulnerable populations. Other characteristics such as sexual orientation (LGBQ), gender identity (non-cis or transgender), disability status, religion or spirituality, SES-disadvantaged backgrounds, and country of origin will also be considered in our research. The Center's Administrative Core is focused on supporting research to address these issues in real world applications of a precision ecological approach among diverse populations to improve public health. The Administrative Core will be responsible for coordinating and overseeing the scientific and administrative activities of the Center, including the overall aims, internal and external communications, compliance, evaluation, and sustainability. We will evaluate the productivity, effectiveness, and appropriateness of Center activities; determine criteria for center affiliations, and foster collaborations throughout NYU with researchers studying MetS, T2D, CVD, and related chronic conditions. All activities will align with the Center's overall goal of supporting research on biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors that underlie MetS and related MCC, to improve health care outcomes and reduce health disparities.