PHORA: A Clinical Decision Support Tool for Patients with Pulmonary Arterial Hypertension

摘要 本应用旨在开发一个多平台的肺癌临床决策支持系统 内科医生的动脉高血压(PAH)，Phora(肺动脉高压结局风险 评估)，可用于：(A)指导治疗决策和(B)优化临床试验设计。我们 将通过利用PAH中几个大型已完成试验数据库的临床试验数据来实现这一目标 正在进行的PAH登记(REWAGE)，以及与医生的观察性会议。拟议的AIMS共同- 创建包含多学科专业的CDSS，包括生物医学工程、高级 PAH医师、计算机科学(机器学习/数据挖掘)、人机交互和相关专业 医疗保健专家。我们的目的是让所有利益攸关方达成共识，从而确保 将Phora接受到实践中。该项目的成功完成将为 前瞻性的多中心试验，将根据患者的长期结果评估Phora。 最终目的是传播这一资源，以提高效率、效果和成本- 此疗法治疗PAH的有效性。

ABSTRACT This application seeks to develop a multi-platform clinical decision support system (CDSS) in pulmonary arterial hypertension (PAH) for physicians, PHORA (Pulmonary Hypertension Outcomes Risk Assessment), which can be used to: (a) guide therapeutic decisions and (b) optimize clinical trial design. We will achieve this goal by utilizing clinical trial data from several large databases of completed trials in PAH, an ongoing PAH registry (REVEAL), as well as observational sessions with physicians. The proposed aims co- create the CDSS with a multi-disciplinary group of specialties including: biomedical engineering, advanced PAH physicians, computer science (machine learning/data mining), human computer interaction, and allied health care experts. Our intention is to engage all stakeholders to achieve consensus and thereby assure the acceptance of PHORA into practice. Successful completion of this project will lay the foundation for a prospective, multi-center trial in which PHORA will be evaluated with respect to long-term patient outcomes. The ultimate aim is to disseminate this resource so as to improve the efficiency, efficacy, and cost- effectiveness of this treatment for PAH.