A Structured Approach to the Design of Minimally Traumatic Blood Pumps

项目摘要/摘要 这项研究的目标是开发改进的分析和实验方法，用于结构化的 减少不良事件的可能性的血泵的设计方法。我们建议继续我们的 工作重点是使用开放源码开发计算平台，该平台集成了 和夫妇剪切性血液损伤，血栓易感性，血小板激活，和 在设计过程中同时建立血栓模型。目前，只有溶血模型用于 设计阶段和血小板激活在极少数情况下使用，但两者都没有整合到单一的 同时建立计算模型。我们使用大涡模拟计算流体力学(CFD) 提供了捕获大部分湍流流场的流场。我们将把这种结构化方法应用于 我们正在开发的原型叶片式旋转心室辅助装置(VAD)。为了实现这些目标，我们 将重点关注以下具体目标： 1.整合了一个新开发的基于耗散(7)的剪切性血液损伤模型(血栓形成 易感电位(TSP)(8-10)和血小板激活模型(11)合并为单一计算 这是一款设计旋转式血泵的平台，融合了VAD和天然心脏搏动性的相互作用。 这项研究旨在最终纳入基于连续介质的宏观血栓形成模型，以 完善泵的设计。 2.建立了基于连续介质的层流、湍流和剪切宏观血栓模型 诱导的血小板激活，将用于改进泵的设计。血栓形成的模型将是 通过使用旋转盘系统(RDS)的体外血小板黏附研究进行验证，体外反向 采用全血正向台阶(BFS)模型，与临床LVAD患者对照。 3.在非抗凝动物体内进行旋转式VAD系统原型的动物研究 评估血栓形成和栓塞的位置、严重程度和时间进程，b)研究泵的作用 速度和脉动血流，以及c)测量血小板活化、整体凝血和溶血。 这项研究将以结构化的方法产生改进的设计和分析工具，适用于 广泛的血泵和血液接触式心血管设备。

Project Summary / Abstract The objective of this research is to develop improved analytical and experimental methods used in a structured approach for the design of blood pumps with reduced potential for adverse events. We propose to continue our efforts focusing on the development of a computational platform using an open source code that integrates and couples shear-induced blood damage, thrombosis susceptibility potential, platelet activation, and thrombosis models simultaneously during the design process. Currently, only hemolysis models are used in the design phase and platelet activation used in rare cases, but neither has been integrated into a single computational model simultaneously. Our use of large eddy simulation computational fluid dynamics (CFD) provides a flow field capturing much of the turbulent flow field. We will apply this structured approach on a prototype bladed rotary ventricular assist device (VAD) that we are developing. To accomplish these goals, we will focus on the following specific aims: 1. Integrate a newly developed shear-induced blood damage model based upon dissipation (7), a thrombosis susceptibility potential (TSP) (8-10), and a platelet activation model (11) into a single computational platform to design a rotary blood pump incorporating the interaction of the VAD and native heart pulsatility. This research is intended to culminate in inclusion of a continuum-based macroscopic thrombosis model to refine the pump design. 2. Develop a continuum-based macroscopic thrombosis model for both laminar and turbulent flow and shear induced platelet activation that will be used to refine the pump design. The thrombosis model will be validated through in vitro platelet adhesion studies using a rotating disk system (RDS), an in vitro backward facing step (BFS) model using whole blood, and clinical LVAD patients. 3. Perform in vivo animal studies of a prototype rotary VAD system in non-anticoagulated animals to a) assess location, severity, and time course of thrombosis and embolization, b) study the effect of pump speed and pulsatile flow, and c) measure platelet activation, global coagulation, and hemolysis. This research will yield improved design and analysis tools in a structured approach that will be applicable to a broad range of blood pumps and blood contacting cardiovascular devices.