Signaling Pathways in Innate Immunity

在相对年轻的领域，现代免疫学的知识出现了前所未有的扩展。 先天免疫力。先天免疫中的信号通路(SPII)培训资助(TG)计划 而博士后研究人员仅处于支持的第五个年头，而且正在蓬勃发展。马里兰大学商学院 医学(UMSOM)在这一领域拥有强大的研究和培训实力。培训助学金学院 (转化生长因子)这一独特的，高度集中的计划是高度互动的，主要来自该部 微生物学和免疫学系，隶属于跨学科中心和研究所，包括该中心 疫苗研发，基因组科学研究所，血管和炎症性疾病中心， Greenebaum癌症中心和人类病毒学研究所。28个转化生长因子有着悠久的历史 在赠款和出版物方面进行合作，并且是资金充足的赠款私人投资机构，每年总计约1310万美元 直接成本。博士前实习生将主要从#年的跨部门研究生计划中挑选出来 生命科学(GPILS)项目分子微生物学和免疫学(MMI)，一个著名的博士学位。 该计划包括严格的核心课程、特定于计划的课程、选修课、期刊俱乐部、 研讨会、年度座谈会和研究生研究报告日。额外的学术工作将是 结合转化生长因子指导下的学位论文研究要求进行实验室培训 其记录在案的专业知识将提供跨学科和多学科的培训机会。博士前 学生是从越来越合格的申请者中挑选出来的，也是从UMSOM医学博士/博士学位中挑选出来的。 程序。同样，我们符合TG标准的博士后实习生越来越倾向于拥有 在先天免疫信号方面的专业知识，他们使用最先进的资源接受专门的指导。 博士后和博士后实习生都有额外的授课和非授课要求，包括培训 在负责任的研究、专业发展和高度结构化的指导计划中。 从代表性不足的少数族裔中招募受训人员，通过旨在 在促进我们项目的成功方面，这一点反映在我们学员的多样性上：20个培训名额中的13个 (65%)分配给妇女，25%分配给任职人数不足/残疾的个人。我们的TG计划是由一个 高素质的咨询委员会，包括培训计划主任、两名联席主任和具有 重要的TG经验。个人责任，包括坚持科学的严谨性和重复性， 并参与科学推广计划，这是我们的转化生长因子使用创新的新技术而受到的强烈鼓励 培训部分。我们的学员已经建立了优秀的出版物和奖项记录，并且 一些人已经接受了研究职位，或者已经离开去接受额外的培训，这提供了一个早期的 表明我们的学员将继续为未来在学术界的职业生涯做好非常充分的准备， 最终将对国家健康做出重大贡献的政府和行业。

An unprecedented expansion of knowledge in modern immunology has occurred in the relatively young field of innate immunity. The “Signaling Pathways in Innate Immunity” (SPII) training grant (TG) program for pre- and post-doctoral fellows is only in its 5th year of support and is thriving. The University of Maryland School of Medicine (UMSOM) has significant research and training strengths in this area. The Training Grant Faculty (TGF) for this unique, highly focused program are highly interactive and primarily drawn from the Department of Microbiology and Immunology, with affiliations in interdisciplinary centers and institutes including the Center for Vaccine Development, Institute for Genome Sciences, Center for Vascular and Inflammatory Diseases, Greenebaum Cancer Center, and the Institute of Human Virology. The 28 TGF have a longstanding history of collaboration on grants and publications, and are well funded PIs of grants totaling ~$13.1 million in annual direct costs. Predoctoral trainees will be selected primarily from the interdepartmental Graduate Program in Life Sciences (GPILS) Programs in Molecular Microbiology & Immunology (MMI), a well-established Ph.D. Program that includes a rigorous core curriculum, program-specific courses, elective courses, journal clubs, seminars, annual symposia, and graduate research presentation days. Additional academic work will be combined with demanding laboratory training through dissertation research under the direction of the TGF whose documented expertise will provide inter- and multidisciplinary training opportunities. Predoctoral students are selected from an increasingly qualified applicant pool, as well as from the UMSOM M.D./Ph.D. Program. Similarly, our TG-eligible postdoctoral trainees are increasingly gravitating to laboratories with expertise in innate immune signaling where they receive dedicated mentoring, using state-of-the art resources. Both pre- and postdoctoral trainees have additional didactic and non-didactic requirements, including training in the responsible conduct of research, professional development, and a highly structured mentoring program. Recruitment of trainees from underrepresented minorities is given significant priority through programs aimed at facilitating success in our program, and is reflected in the diversity of our trainees: 13 of 20 training slots (65%) went to women and 25% to underrepresented/disabled individuals. Our TG Program is guided by a highly qualified Advisory Board including the Training Program Director, two Co-Directors, and individuals with significant TG experience. Personal responsibility, including an insistence on scientific rigor and reproducibility, and participation in scientific outreach programs, are strongly encouraged by our TGF using innovative new training components. Our trainees are already building excellent records of publications and awards, and several have already accepted research positions or have left for additional training, providing an early indication that our trainees will continue to be exceptionally well prepared for future careers in academia, government, and industry that will, ultimately, contribute to the nation’s health in significant ways.