Identification of chemical and biological determinants, their sources, and strategies to promote healthier homes in Europe

INQUIRE旨在通过提供知识，工具和措施来保护公民健康，以大幅改善室内空气质量（IAQ）。我们将开展研究和评估创新行动，以减少家庭中的危险化学和生物决定因素，对居民的健康产生积极影响。INQUIRE将特别关注婴儿和幼儿（<5岁），因为他们是高度敏感的群体，在家庭环境中度过了相当长的时间。INQUIRE将通过实施创新的、低成本的、非侵入性的采样策略（传感器、室内/室外被动采样、尿液生物监测）来全面推进我们对家庭室内空气质量决定因素的理解，以表征家庭室内空气质量的决定因素及其对人类暴露的重要性。为了了解欧洲室内空气质量的决定因素，该研究将对分布在8个国家的200多个家庭进行为期一个月的监测，涵盖每个国家的条件梯度。分层的高分辨率化学和生物筛选技术和大范围的整体表征的危害将提供一个全面的评估室内空气质量的决定因素。多方面的数据分析技术（包括机器学习、暴露建模、地理空间分析）将把化学、生物和毒性概况与室内空气质量的驱动因素联系起来，以确定污染源并对污染物进行优先排序。来源识别将直接用于测试新技术和易于部署的改善室内空气质量的策略，从而产生基于证据的建议和制定室内空气质量标准的政策策略草案。INQUIRE的开放科学方法和生成的关于危险决定因素、其影响、风险因素和来源的公平数据将支持对结果的持续利用。公开传播所产生的知识将提高公民的认识，而工业界和决策者的利用将支持向零污染家庭过渡。INQUIRE项目是欧洲室内空气质量和健康集群的一部分（名称和缩写待定）

INQUIRE aims to protect citizen health by providing knowledge, tools, and measures to substantially improve indoor air quality (IAQ). We will conduct research and evaluate innovative actions to reduce hazardous chemical and biological determinants in homes, positively impacting the health of residents. INQUIRE will focus particularly on infants and young children (<5years old) as highly sensitive groups that spend a substantial time in the home environment. INQUIRE will comprehensively advance our understanding of the determinants of IAQ in homes by implementing innovative, low cost, non-invasive sampling strategies (sensors, indoor/outdoor passive sampling, urine biomonitoring) to characterize determinants of household IAQ and their importance to human exposure. To capture the breath of IAQ determinants across Europe, the study will monitor for one month over 200 homes distributed across 8 countries, covering a gradient of conditions in each country. Tiered high-resolution chemical and biological screening techniques and wide-scope holistic characterization of hazards will provide a comprehensive assessment of the determinants of IAQ. Multifaceted data analysis techniques (including machine learning, exposure modelling, geospatial analysis), will link chemical, biological and toxicity profiles with drivers of IAQ to identify sources and prioritize pollutants. Source identification will feed directly into the testing of both novel technologies and readily deployable strategies to improve IAQ, resulting in evidence-based recommendations and a draft of policy strategy for developing IAQ standards. INQUIREs Open Science approach and generated FAIR data on hazardous determinants, their effects, risk factors and sources will endorse continuous exploitation of results. Open dissemination of generated knowledge will raise citizen awareness while exploitation by industry and policy makers will endorse a transition towards homes with zero pollution. The project INQUIRE is part of the European cluster on indoor air quality and health (name and acronym to be decided)