Biostatistics and Bioinformatics

项目摘要 生物统计学和生物信息学共享资源核心2的目的是提供咨询和 就所有SPORE项目、开发项目和管理核心的定量方法进行协作， 共享资源核心1.项目负责人和生物统计学家之间的成功合作， 计算生物学家在这个孢子，以及其他核心的成员，是必不可少的实现 项目的目标。该核心的成员将为设计、分析和报告提供支持， 实验室、动物、转化、基因组和临床研究。根据项目的不同，这些合作 范围从短期磋商到大型合作项目，并将包括协助筹备 与SPORE项目有关的拨款申请和手稿。核心成员还将提供 为研究人员提供统计和生物信息学指导，特别强调职业发展 获奖者和发展项目调查员。对于SPORE的成功来说，重要的是协调 数据管理和质量控制程序。生物统计学家和计算生物学家是 DFCI的这一过程的组成部分，并将继续提供现有程序的投入，以及 关于额外计算基础设施的建议，这可能是这个孢子所必需的。到 为了实现SPORE的目标，我们提出以下具体目标： 具体目标1。为SPORE项目提供计算生物学和生物信息学合作， 开发项目和核心。这包括设计，预处理，存储和分析所有高 通过基因组研究。 具体目标2。为SPORE项目、开发项目和 丹这包括实验室和临床方案的设计、实施、分析和报告;包括 实验室结果与患者特征和临床研究结局的协调。 具体目标3。为SPORE研究人员提供咨询和统计教育。为了培养严谨性， 为了确保SPORE中所有计算活动的可重复性，核心还将提供或推荐支持 用于数据收集、表单开发、数据处理和质量保证的计算基础设施 临床试验数据，以及在实验室、动物和相关临床研究的数据库之间移动数据。

PROJECT SUMMARY The purpose of the Biostatistics and Bioinformatics Shared Resource Core 2 is to provide consultation and collaboration on quantitative methods on all SPORE Projects, Developmental Projects, and Admin Core and Shared Resource Core 1. Successful collaboration between the project leaders and the biostatisticians and computational biologists in this SPORE, as well as members of the other Cores, is essential to achieve the goals of the projects. Members of this core will provide support for the design, analysis, and reporting of laboratory, animal, translational, genomic, and clinical studies. Depending on the project, these collaborations could range from short consultations to large collaborative projects, and will include assistance in preparation of grant applications and manuscripts related to the SPORE projects. The Core members will also provide statistical and bioinformatics mentoring to the researchers, with a particular emphasis on Career Development Awardees and Developmental Project Investigators. Important for the success of the SPORE is the coordination of data management and quality control procedures. The biostatisticians and computational biologists are an integral part of this process at the DFCI, and will continue to provide input on the existing procedures, as well as recommendations on additional computational infrastructure, which might be necessary for this SPORE. To achieve the goals of the SPORE, we propose the following specific aims: Specific Aim 1. To provide computational biology and bioinformatics collaboration for SPORE Projects, Developmental Projects, and Cores. This includes design, preprocessing, storage, and analysis of all high throughput genomic studies. Specific Aim 2. To provide biostatistical collaboration for SPORE Projects, Developmental Projects, and Cores. This includes design, conduct, analysis and reporting of laboratory and clinical protocols; including the coordination of laboratory results with patient characteristics and outcomes from the clinical studies. Specific Aim 3. To provide consulting and statistical education to SPORE researchers. To foster rigor and reproducibility of all computational activities in the SPORE, the core will also provide or recommend supporting computational infrastructure for data collection, form development, data processing, and quality assurance of clinical trials data, as well as moving data between databases for laboratory, animal, and relevant clinical studies.