Core 5 - Biostatistics and Bioinformatics Core
Core 5 - Biostatistics and Bioinformatics Core
批准号:
10555739
负责人:
Giovanni Luigi PARMIGIANI
金额:
$21.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
未结题
起止时间:
2011-12-01 至 2028-07-31
关键词:
AddressAutologous Stem Cell TransplantationBasic ScienceBehaviorBioinformaticsBiologyBiometryCellsClinicalClinical ResearchClinical TrialsCollaborationsColorDNA Sequence AlterationDana-Farber Cancer InstituteDataData AnalysesDatabasesDependenceDevelopmentDiagnosisDiseaseDisease remissionEvaluationFundingGenetic TranscriptionGenomicsGoalsGrantHeterogeneityHigh Dose ChemotherapyImmunotherapyIndividualInternationalMaintenanceMaintenance TherapyMediatingMethodsMultiple MyelomaNeoadjuvant TherapyOncogenicPatientsPhase III Clinical TrialsPhysical condensationProceduresProcessQuality ControlRNARNA BindingRandomizedRegulationResearchResearch PersonnelResistanceResolutionRiskRoleSamplingSiteSpecimenStratificationTherapeuticTissue BanksTreatment ProtocolsWorkWritingcancer genomicsclinically relevantdata exchangedata warehousedesignepigenomicshigh throughput analysismembernext generationnext generation sequencingnovel strategiesnovel therapeuticsoutcome predictionphase 3 studypre-clinicalprogramsresponsesuccesssurvival outcometranscriptomics
中文摘要
项目总结-核心5 -生物统计学和生物信息学核心丹娜-法伯癌症研究所
英文摘要
Project Summary – Core 5 – Biostatistics and Bioinformatics Core Dana-Farber Cancer Institute
Studies from the previous grant period confirmed that achieving MRD negative status provides significantly
superior progression free and overall survival outcome. Moreover, the studies by IFM have shown that high dose
chemotherapy followed by autologous stem cell transplant (HDT) provide significant PFS benefit. With the help
of this Core, the results of the DFCI sites (determination study) were just recently unblinded showing a significant
benefit of HDT even with maintenance till progression. With the help of this Core, the new proposal for clinical
study was developed in this renewal application to address how MRD status can inform the therapeutic approach.
The proposal is to perform a randomized phase III study comparing HDT versus additional cycles of induction
therapy for MRD negative patients and single versus tandem HDT for MRD positive patients. Moreover along
with clinical information a large amount of genomic and epigenomic data has been generated using the patients
samples that requires integrated analysis. In the prior funding period the Core has supported all the projects with
planning, analysis and integration. In this proposal Core will continue to support this effort and will provide 1)
support and direction on the formatting, quality control and annotation procedures of clinical and research data
as well as the process of transferring the research data a data warehouse for integrative analysis, 2)
bioinformatics support for primary and integrative analysis of the high-throughput data and 3) biostatistics support
in terms of design and analysis for all projects. Core members will work closely with all project members as well
as Cores 1 and 2 with regard to quality control, specimen tracking and data transfer procedures as well as Cores
3 and 4 which will perform next generation sequencing for identifying genomic, epigenomic and transcriptomic
changes at bulk and single cell level. Bioinformatics and biostatistics support and analysis is not only required
for individual projects, but it is crucial for the integrative analysis from data across the projects and thus overall
success of the program.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Statistical methods for cancer mutational signatures
-
批准号:10662461
-
项目类别:
-
资助金额:$23.11万
-
财政年份:2021
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Statistical methods for cancer mutational signatures
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批准号:10278549
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项目类别:
-
资助金额:$41.7万
-
财政年份:2021
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Statistical methods for cancer mutational signatures
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批准号:10439883
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项目类别:
-
资助金额:$39.11万
-
财政年份:2021
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Bioinformatics Tools for Genomic Analysis of Tumor and Stromal Pathways in Cancer
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批准号:8606837
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项目类别:
-
资助金额:$31.48万
-
财政年份:2013
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Bioinformatics Tools for Genomic Analysis of Tumor and Stromal Pathways in Cancer
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批准号:8458359
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项目类别:
-
资助金额:$36.85万
-
财政年份:2013
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Novel Tools for Familial Risk Prediction
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批准号:8530798
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项目类别:
-
资助金额:$22.5万
-
财政年份:2013
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Novel Tools for Familial Risk Prediction
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批准号:8628822
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项目类别:
-
资助金额:$18.13万
-
财政年份:2013
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Core 5: Biostatistics and Bioinformatics
-
批准号:10226190
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项目类别:
-
资助金额:$16.6万
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财政年份:2011
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负责人:Giovanni Luigi PARMIGIANI
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依托单位:
BIOINFORMATICS
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批准号:7304725
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项目类别:
-
资助金额:$12.26万
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财政年份:2006
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负责人:Giovanni Luigi PARMIGIANI
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依托单位:
Predoctoral Biostatistics Training in Genesis/Genomics
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批准号:7123200
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项目类别:
-
资助金额:$14.15万
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财政年份:2006
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Biostatistics and Bioinformatics Core
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批准号:7212437
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项目类别:
-
资助金额:$11.48万
-
财政年份:2006
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Predoctoral Biostatistics Training in Genetics/Genomics
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批准号:7269397
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项目类别:
-
资助金额:$12.99万
-
财政年份:2006
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Predoctoral Biostatistics Training in Genetics/Genomics
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批准号:7484236
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项目类别:
-
资助金额:$12.99万
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财政年份:2006
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Statistical Methods for Cancer Genes
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批准号:7270423
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项目类别:
-
资助金额:$13.8万
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财政年份:2004
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负责人:Giovanni Luigi PARMIGIANI
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依托单位:
Statistical Methods for Cancer Genes
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批准号:7120023
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项目类别:
-
资助金额:$24.4万
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财政年份:2004
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负责人:Giovanni Luigi PARMIGIANI
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依托单位:
Statistical Methods for Cancer Genes
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批准号:6875297
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项目类别:
-
资助金额:$26.68万
-
财政年份:2004
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Statistical Methods for Cancer Genes
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批准号:6954648
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项目类别:
-
资助金额:$25.04万
-
财政年份:2004
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Biostatistics and Bioinformatics
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批准号:10194387
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项目类别:
-
资助金额:$21.15万
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财政年份:2003
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负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Biostatistics and Bioinformatics
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批准号:10653110
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项目类别:
-
资助金额:$19.67万
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财政年份:2003
-
负责人:Giovanni Luigi PARMIGIANI
-
依托单位:
Biostatistics and Bioinformatics
-
批准号:10449083
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项目类别:
-
资助金额:$19.67万
-
财政年份:2003
-
负责人:Giovanni Luigi PARMIGIANI
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依托单位:
海外基金