Mental Health Research Network III

基于实践的研究有可能大大提高速度，效率，相关性和影响力 心理健康临床和服务研究。实现这些成果需要基于实践的研究 能够预测和适应精神卫生保健服务变化的网络，包括： ·研究完全嵌入现实世界的实践 ·研究目标与患者和卫生系统利益相关者的优先事项保持一致 ·可用于快速分析的大规模数据基础设施 ·信任和透明的文化，以促进协作学习和改进 我们建议扩大现有的心理健康研究网络（MHRN），以包括14个研究中心 该系统为16个州的2 500多万患者提供服务。MHRN 基础设施将得到加强，以支持下一代基于实践的网络，包括： ·增加患者、卫生系统领导者和其他利益相关者对网络治理的参与 ·一个扩展的公共开源软件工具和其他技术资源库 ·开展可行性试点项目和快速回应利益攸关方询问的更正式程序 ·扩大与外部利益攸关方和研究伙伴的联系 此总体应用程序请求支持一个管理核心、一个方法核心和四个研究 项目行政核心将支持所有网络活动，包括正在进行的附属研究 项目，本次申请中提出的新研究项目，以及未来开发的新项目 融资周期。一个组织单位将包括行政领导、治理、战略规划和 负责财务管理和法规遵从性。外展和外部合作 该股将负责利益攸关方的参与，并与新的研究伙伴开展合作。 新问题股将支持及时应对新出现的科学和公共卫生问题。的 核心方法将支持在所有网络研究中优化使用现有方法，并开发新的 解决高度优先的公共卫生问题的方法。信息股将维持和改进 网络数据基础设施和传播网络开发的信息资源。进行科学分析的基础上 该单位将专注于提高网络项目的方法论严谨性和创新分析的发展 以利益相关者需求为导向的方法。这些基础设施资源将支持两项Signature研究 项目（对围产期抑郁症的电子保健干预措施的务实试验和对新的 两个试点研究项目（一项针对自杀风险的药物研究）和两个针对自杀风险的药物研究项目（一项针对自杀风险的药物研究）。 实施自杀风险预测模型的观点和一项旨在减少 抑郁症治疗起始的差异）。

Practice-based research has the potential to dramatically improve the speed, efficiency, relevance, and impact of mental health clinical and services research. Realizing those gains will require a practice-based research network capable of anticipating and adapting to changes in mental health care delivery, including: • Research fully embedded in real-world practice • Alignment of research goals with priorities of patient and health system stakeholders • Large-scale data infrastructure available for rapid analysis • A culture of trust and transparency to facilitate collaborative learning and improvement We propose to expand the existing Mental Health Research Network (MHRN) to include 14 research centers embedded in health systems serving a combined population of over 25 million patients in 16 states. MHRN infrastructure will be enhanced to support a next-generation practice-based network, including: • Increased engagement of patients, health system leaders, and other stakeholders in network governance • An expanded public, open-source library of software tools and other technical resources • More formal processes for conducting feasibility pilot projects and rapid response to stakeholder queries • Expanded outreach to external stakeholders and research partners This Overall application requests support for an Administrative Core, a Methods core, and four research projects. The Administrative Core will support all network activities, including ongoing affiliated research projects, new research projects proposed in this application, and new projects developed during the coming funding cycle. An Organizational Unit will include executive leadership, governance, strategic planning, and responsibility for financial management and regulatory compliance. An Outreach and External Collaboration Unit will be responsible for stakeholder engagement and developing collaborations with new research partners. An Emerging Issues Unit will support timely responses to emerging scientific and public health questions. The Methods Core will support optimal use of existing methods across all network research and develop new methods to address high-priority public health questions. An Informatics Unit will maintain and improve network data infrastructure and disseminate network-developed informatics resources. A Scientific Analysis Unit will focus on improving the methodologic rigor of network projects and development of innovative analytic methods driven by stakeholder needs. These infrastructure resources will support two Signature research projects (a pragmatic trial of eHealth interventions for perinatal depression and a real-time evaluation of new medications to address suicide risk) and two Pilot research projects (an investigation of stakeholder perspectives on implementation of suicide risk prediction models and a pilot trial of outreach to reduce disparities in depression treatment initiation).