Operations Core

运营核心（OC）通过招募支持OAIC对多因素老年疾病的调查 并留住不同的老年人群体，在研究中寻求当地社区的投入 规划和传播，监测参与者安全，确保法规合规性，开展调查 和仪器，设计信息技术（IT）系统，以实施研究，收集和 为统计分析准备数据，并提供跨项目的连续性和共享知识。的 OC（RC 1）的总体目标是确保成功实施以多因素为重点的研究， 老年人的条件。这一目标将通过领导，管理和协调有效的， 有效和创新地利用设施、数据、人员、资源和空间。有一个一致的需求， 经验丰富的人员，能够快速执行以衰老为重点的研究， 信息学技能和技术，以简化工作。 OC的具体目标是：1）提供适合支持耶鲁OAIC资助的基础设施 项目和外部项目。这一基础设施包括有经验的人员、工作人员培训模块， 开展实地研究的标准操作规程和全面的临床研究信息学 (CRI)2）与REC、PESC和生物统计核心（RC 2）合作，制定具体的CRI， 耶鲁OAIC资助项目和外部项目的现场操作系统;以及3）进行创新的OC 发展项目，推进耶鲁OAIC的使命。 在当前供资周期（2013年至今），业务核心整体参与了研究工作 支持80个OAIC资助的项目和外部项目，耶鲁大学内部的许多合作， 与其他几家胡椒中心合作。这些努力总共产生了114项同行审查结果， 出版物和81个校外资助的赠款（超过1.45亿美元的总成本），其中25个涉及18个初级教师 专门从事老龄化/老年医学研究。在下一个资助周期内，法团将：（1）就 5个拟议的REC和PESC项目，29个资助的外部项目中的24个，以及7个待批准的赠款项目 （2）大幅扩展及加强临床服务， 与各个临床的领导者合作，研究耶鲁医学院的信息学基础设施 研究支持中心;（3）领导创新发展项目，临床决策支持 系统（CDSS）工具包，这将使任何研究团队都可以访问REDCap， 实施一个复杂的、受HIPAA保护的CDSS。CDSS工具包将支持相关项目的增长， OAIC分主题为患有多种慢性病的老年人做出个性化决策。

The Operations Core (OC) supports OAIC investigations of multifactorial geriatric conditions by recruiting and retaining diverse populations of older persons, seeking input from the local community in research planning and dissemination, monitoring participant safety, ensuring regulatory compliance, developing surveys and instruments, designing Information Technology (IT) systems to implement research, collecting and preparing data for statistical analysis, and providing continuity and shared knowledge across projects. The overall goal of the OC (RC1) is to ensure the successful implementation of research focused on multifactorial geriatric conditions. This goal will be accomplished by leading, managing, and coordinating the effective, efficient and innovative use of facilities, data, staff, resources, and space. There is a consistent demand for experienced personnel with the ability to quickly execute aging-focused research and an increasing need for informatics skills and technology to streamline work. The Specific Aims of the OC are: 1) to provide an infrastructure suitable to support Yale OAIC-funded projects and External Projects. This infrastructure includes experienced personnel, staff training modules, standard operating procedures for conducting field studies, and comprehensive clinical research informatics (CRI) services; 2) to collaborate with the REC, PESC, and Biostatistics Core (RC2) to develop specific CRI and field operations systems for Yale OAIC-funded projects and External Projects; and 3) to conduct innovative OC Development Projects that advance the mission of the Yale OAIC. During the current funding cycle (2013-present), the Operations Core was integrally involved in research support of 80 OAIC-funded projects and External Projects, numerous collaborations within Yale, and engagement with several other Pepper Centers. Altogether, these efforts have resulted in 114 peer-reviewed publications and 81 extramurally funded grants (>$145 million total costs) of which 25 involved 18 junior faculty specializing in aging/geriatrics research. During the next funding cycle, the OC will: (1) collaborate on 4 of the 5 proposed REC and PESC projects, 24 of the 29 funded External Projects, and 7 pending projects from grant submissions involving more than $13 million in total costs; (2) substantially expand and enhance the clinical research informatics infrastructure at Yale School of Medicine, in partnership with leaders from each clinical research support center; and (3) lead an innovative Development Project, the Clinical Decision Support System (CDSS) Toolkit, that will make it possible for any research team having access to REDCap to implement a sophisticated, HIPAA-secure CDSS. The CDSS toolkit will support the growth of projects related to the OAIC subtheme of individualized decision making for older persons with multiple chronic conditions.