Risk and Resilience in Developmental Diversity and Mental Health

患有精神健康(MH)疾病的个人及其家人，特别是那些患有高度普遍的神经发育障碍(NDDS)的人，面临着高度的歧视和耻辱，这严重影响了他们的身心健康。我们处于非药物依赖性药物研究前沿的世界领先的合作小组将启动一个新项目--？精神卫生中的风险、复原力和发展多样性？(R2D2-MH)。我们提出了双重范式转变，以改善MH患者及其家人的福祉。我们将(I)从以风险为重点的研究转向理解和促进复原力，以及(Ii)从基于诊断的方法转向将定义人类一生的福祉和功能的发展多样性方法。R2D2-MH旨在确定遗传和环境保护/复原力因素及其如何影响发育多样性和MH。我们将在多个水平上调查MH疾病的两个非常普遍的早期风险：早产和NDDS的遗传责任。我们的项目有四个主要目标1.提供欧洲最大的关于人类早期大脑发育和MH结果的多尺度数据集；2.确定对NDD不利影响的复原力的生物机制；3.与利益相关者共同开发新的数字工具，以增加参与性研究/医学并减少耻辱；4.建立预测模型，以指导个性化干预。R2D2-MH综合了欧洲、以色列和澳大利亚的跨学科和互补性专业知识，涵盖伦理学、流行病学、社会学、遗传学、细胞生物学、神经科学、计算建模、信息技术、心理学和精神病学。我们的研究高度投入：它将参与者和患者纳入研究，以确保我们的预期结果真正具有转化性，并将有助于减轻MH患者的耻辱和负担。没有公开描述

Individuals with mental health (MH) conditions and their families, especially those with highly prevalent neurodevelopmental disorders (NDDs), are exposed to high levels of discrimination and stigma, which significantly affects their physical and mental well-being. Our world-leading collaborative group at the forefront of research in NDDs will launch a new project - ?Risk, Resilience and Developmental Diversity in Mental Health? (R2D2-MH). We propose a double paradigm shift to improve the wellbeing of people with MH conditions and their families. We will move (i) from risk-focused studies towards understanding and promoting resilience, and (ii) from a diagnosisbased approach to a developmental diversity approach that will define wellbeing and functioning across the human lifespan. R2D2- MH aims to identify genetic and environmental protective/resilience factors and how they influence developmental diversity and MH. We will investigate at multiple levels two highly prevalent early risks for MH conditions: prematurity and genetic liability for NDDs. Our project has four main ambitions 1. Provide the largest European multi-scale dataset on early human brain development and MH outcomes; 2 Identify biological mechanisms of resilience to the adverse effects of NDD; 3. Co-develop, with the stakeholders, new digital tools to increase participatory research/medicine and reduce stigma; 4. Establish predictive models to guide personalised interventions. R2D2-MH integratesinterdisciplinary and complementary expertise across Europe, Israel, and Australia that covers ethics, epidemiology, sociology, genetics, cell biology, neuroscience, computational modelling, Information Technology, psychology, and psychiatry. Our research is highly engaged: it embeds participant and patient involvement in research to ensure that our expected outcomes are truly translational, and will help to reduce stigma and burden for individuals with MH conditions.no public description