Enrichment Program

项目摘要--丰富方案 慢性肾脏疾病影响着3000多万美国人，使他们面临着患心血管疾病的主要风险。 大病、其他合并症和死亡，并利用约28%的年度医疗保险预算。这些令人担忧的 统计数据强调，迫切需要确定新的、成本效益高的治疗方法。该计划的主要目标是 西北大学乔治·M·奥布莱恩肾脏研究核心中心(NU-GoKIDNEY)正在推动 并支持发现新的治疗方法的研究，这些治疗方法将改变预防和 治疗肾脏疾病，并最终导致治愈。拟议的铀浓缩计划是一项重要的 拟建的努戈基德尼·奥布莱恩中心的组成部分，旨在：向中心调查人员提供信息 相关研究的最新进展；通过培训壮大肾脏疾病翻译队伍 临床和基础科学研究人员推进治疗发现研究，并通过 吸引其他相关领域的研究人员进入肾脏研究；并催化跨学科 合作需要开发创新的解决方案，以克服开发治疗的障碍。 因此，丰富方案将支持一些教育活动和研究场所 旨在将来自不同背景-临床和基础肾脏的教职员工和实习生聚集在一起 研究人员、化学家、物理学家、药理学家和纳米医学专家。特定组件 丰富计划的内容包括：1)一系列强有力和全面的说教和 以课堂为基础的研讨会、课程和会议，以突出肾脏研究的最新进展并 培训和支持肾脏治疗开发方面的新研究人员。2)一系列跨学科的活动 包括研讨会和科学讲座，涉及奥布莱恩中心的基础科学和临床教职员工以及他们的 实习生。3)一年一度的奥布莱恩中心研讨会，重点是确定所有阶段的治疗目标 发现号。4)科学-高中外展计划，从以下方面识别和指导高积极性的学生 在科学和肾脏研究方面的弱势背景。5)聚焦S咖啡馆系列科普 关于肾脏疾病研究和治疗的进展，在一个创新和互动的论坛上发表， 将包括中心调查人员和非专业公众。铀浓缩计划的另一个目标是提供 为研究人员和其他由NIDDK资助的O‘Brien和 肾脏中心通过我们的侄子中心网站。

PROJECT SUMMARY – ENRICHMENT PROGRAM Chronic kidney diseases affect more than 30 million Americans, placing them at major risk for cardiovascu- lar disease, other comorbidities and death and utilize ~ 28% of the annual medicare budget. These alarming statistics underscore the urgent need to identify new, cost-effective treatments. The major objective of the George M. O'Brien Kidney Research Core Center at Northwestern University (NU-GoKIDNEY) is to promote and support research into the Discovery of Novel Therapeutics that will transform the prevention and treatment of kidney diseases and eventually lead to cures. The proposed Enrichment Program is an essential component of the proposed NU-GoKIDNEY O'Brien Center and is designed to: inform Center investigators of the latest advances in relevant research; grow the kidney disease translational workforce by training investigators in clinical and basic science approaches to advance therapeutic discovery research and by attracting investigators from other, relevant fields into kidney research; and catalyze inter-disciplinary collaborations needed to develop innovative solutions to overcome barriers to developing treatments. Accordingly, the Enrichment program will support a number of educational events and research venues designed to bring together faculty and trainees from diverse backgrounds – clinical and basic kidney investigators, chemists, physical scientists, pharmacologists and nanomedicine experts. Specific components of the Enrichment program include the following: 1) A series of robust and comprehensive didactic and classroom-based seminars, courses and meetings to highlight the latest advances in kidney research and to train and support new investigators in kidney therapy development. 2) A series of cross-disciplinary events including Workshops and Science-Jams, involving O'Brien Center basic science and clinical faculty and their trainees. 3) An annual O'Brien Center symposium focused on identifying therapeutic targets at all stages of discovery. 4) A Sci-High outreach program to identify and mentor highly motivated students from disadvantaged backgrounds in science and kidney investigation. 5) A series of Cafés Scientifiques focused on advances in kidney disease research and treatments, delivered in an innovative and interactive forum that will include Center investigators and the lay public. An additional goal of the Enrichment program is to provide valuable web-based learning resources for investigators and members of other NIDDK-funded O'Brien and Kidney Centers through our nephro-HUB web site.