Translational Research Training in Sleep Medicine

本申请是T32 HL 082610“睡眠医学转化研究培训”的第二次更新， 目前正处于我们第二个5年资助期的第42个月。该计划的主要目标是培养未来 在睡眠医学的转化方法的临床和基础研究人员的一代。未来五年 在此期间，我们建议加强我们对睡眠健康的新兴概念的关注，特别是， 睡眠影响健康的机制，以及对改善健康的睡眠干预措施的评估。我们 哲学是睡眠医学的有效研究培训包括翻译内容， 多学科的教师，和能力为基础的成果。在这一理念的指导下，我们的培训计划 包括：一个主要的重点是指导研究与经验丰富，资金充足的睡眠医学研究人员; 团队指导，与共同导师代表互补的内容和方法领域，并仔细 评估导师和学员的进展;教学工作，包括睡眠研究方法的迷你课程， 对当前文献的批判性评价，专业发展和负责任的研究行为; 可衡量的成果，包括学员出版物、演讲和赠款申请; 在准备职业发展奖申请方面的小组指导; 正式的课程;并获得广泛的培训和研究支持资源的大学 匹兹堡，包括临床和转化科学研究所（CTSI）。培训计划 包括两个部分：1）为国家招聘的医生提供2-3年的博士后培训奖学金 心理学、流行病学和神经科学项目的科学家和博士毕业生。我们建议 保持目前4个博士后的计划规模。2)医学生的研究经验， 包括两个途径：一个为期10周的暑期研究计划和一个纵向学术项目， 完成了四年的医学院学业我们计划每年招收4名医学生参加这些课程。 在我们最初的8年半里，我们的学员取得了相当大的成功：我们的14名博士后发表了 培训期间平均有6.1篇同行评审论文; 12/14提交了F或K奖申请; 7/9的人完成了审查过程（78%）获得了K奖。我们的影响力和成功 培训计划已经扩展到其他皮特项目中以睡眠为重点的博士后，他们由睡眠指导 医学培训学院：所有4名申请者（100%）都获得了职业发展奖。16医疗 学生们提交了12篇摘要，发表了8篇同行评审论文。我们系统地评估了 我们的计划与我们的学员，大学顾问委员会，和外部顾问委员会。基于这些 评估，我们建议进一步加强计划，更有条理的方向，更早的评估 导师-学员“适合”，简化会议和教育计划，技术辅助的多 机构讲习班，并加强招聘医学博士和代表性不足的少数民族学员。

This application is the second renewal of T32 HL082610, “Translational Research Training in Sleep Medicine,” currently in Month 42 of our second 5-year grant period. The broad aim of this program is to train the future generation of clinical and basic researchers in a translational approach to sleep medicine. For the next 5-year period, we propose to sharpen our focus on the emerging concept of sleep health—specifically, on the mechanisms whereby sleep influences health, and the evaluation of sleep interventions to improve health. Our philosophy is that effective research training in sleep medicine incorporates translational content, multidisciplinary faculty, and competency-based outcomes. Guided by this philosophy, our training program includes: A primary focus on mentored research with experienced, well-funded sleep medicine investigators; Team mentoring, with co-mentors representing complementary content and methodologic areas, and careful evaluation of mentor and mentee progress; Didactic work including mini-courses in sleep research methods, critical appraisal of current literature, professional development, and responsible conduct of research; Measurable outcomes, including trainee publications, presentations, and grant applications; Individual and group instruction in the preparation of career development award applications; Individually-prescribed formal coursework; and access to the broad training and research support resources of the University of Pittsburgh, including those of the Clinical and Translational Science Institute (CTSI). The training program includes two components: 1) A 2-3 year postdoctoral training fellowship for nationally-recruited physician scientists and PhD graduates of psychology, epidemiology, and neuroscience programs. We propose to maintain the current program size of 4 postdocs. 2) Research experiences for medical students, which comprise two pathways: a 10-week Summer Research Program and a Longitudinal Scholarly Project running through four years of medical school. We propose to enroll 4 medical students each year in these programs. During our initial 8½ years, our trainees have enjoyed considerable success: Our 14 postdocs have published an average of 6.1 peer-reviewed papers during training; 12/14 have submitted F or K Award applications; and 7/9 who have completed the review process (78%) have received K awards. The influence and success of our training program has extended to sleep-focused postdocs in other Pitt programs who are mentored by Sleep Medicine training faculty: All 4 who applied (100%) received career development awards. Our 16 medical students have submitted 12 abstracts and published 8 peer-reviewed papers. We have systematically evaluated our program with our trainees, University Advisory Board, and External Advisory Board. Based on these evaluations, we propose to further strengthen the program with more structured orientation, earlier evaluation of mentor-mentee “fit,” streamlined meetings and educational programs, technology-assisted multi- institutional workshops, and enhanced recruitment of MD and under-represented minority trainees.