Core A: Administrative Core

摘要 FOA的总体目标是“建立卓越的血清学科学中心， 确定和推进研究机会，以表征SARS-CoV引起的免疫反应， 2病毒感染”。“SARS-CoV 2血清学研究卓越中心”通过以下方式解决了该RFA问题： “进行基础和应用血清学研究，以确定SARS引起的免疫反应的特征， CoV-2病毒感染，了解驱动广泛免疫反应的机制，确定 免疫应答和鉴定疾病发病机理和对未来保护血清学相关性 感染”。行政核心A专门响应这一RFA，因为它的结构是为了管理 并协调与我们中心有关的所有活动。此外，行政核心A将作为联络人， 在血清学科学网络（SeroNet）内的所有卓越中心以及其他 SeroNet的组成部分，包括但不限于血清学科学研究项目（U 01），FNLCR 血清学实验室、血清学能力建设中心和血清学科学网络 协调中心（SSNCC）。行政核心A将提供领导、行政支助和 研究项目1、2和3的基础设施（“项目”）和两个共享资源核心B和C（“核心”）。 我们的行政核心A的其他职责包括确保在整个计划中收集数据 符合SeroNet标准操作规程（SOP）的约定做法和原则， SeroNet指导委员会批准的通用数据元素（CDE）和数据共享计划。因此，在本发明中， 如图1所示，行政核心A将1：财务管理、监督、促进和评估内部 项目与核心之间的项目协作; 2：为人类队列招募提供基础设施， 样本收集、跟踪和共享，3：发展跨血清网合作和合作赠款。作为 在概述中概述，研究中心的研究计划团队已经在智力和技术上高度发达， 整合，建立在许多多维合作的基础上。作为团队结构的一部分，我们建立了 具有不同但互补的作用和责任的层次，将促进综合实验 设计，执行和解释，以解决当前的危机，并使我们能够应用知识 合作。这将得到翻译服务倡议的支持， 招募足够的患者并收集支持项目1-3和核心B所需的样本 和C.此外，它还将产生一个生物/数据库，其中包含跨越自然疾病过程的样本， 治疗干预和潜在的疫苗接种反应。此外，我们的计划的年度研究 务虚会和我们的SeroNet合作试点和可行性赠款机制将连接和整合我们的 计划，项目和核心与更广泛的SeroNet社区进一步推进研究机会， 表征SARS-CoV-2病毒感染引起的免疫应答。

Abstract The overall purpose of the FOA is to “establish Serological Sciences Centers of Excellence with the goal of identifying and advancing research opportunities to characterize the immune responses elicited by SARS-CoV- 2 viral infection”. The “UNC Center for Excellence in SARS-CoV2 Serologic Research” addresses this RFA by “performing basic and applied serological research to characterize the immune responses elicited by SARS- CoV-2 viral infection, understand mechanisms driving the broad immune responses, determine modifiers of the immune response and identify serological correlates of disease pathogenesis and protection against future infection”. Administrative Core A is specifically responsive to this RFA in that it has been structured to manage and coordinate all activities associated with our Center. In addition, Administrative Core A will serve as the liaison between the all Centers for Excellence within the Serological Sciences Network (SeroNet) as well as other components of SeroNet, including but not limited to Serological Sciences Research Projects (U01), the FNLCR Serology Laboratory, Serological Capacity Building Centers (CBC) and a Serological Sciences Network Coordinating Center (SSNCC). Administrative Core A will provide leadership, administrative support and infrastructure for Research Projects 1, 2, and 3 (‘Project’) and two Shared Resource Cores B and C (‘Cores’). Additionl responsibilities of our Administrative Core A include ensuring the data collected across the Program conform with the agreed practice and principles of the SeroNet Standard Operating Procedures (SOPs), Common Data Elements (CDEs) and data sharing plan as approved by the SeroNet Steering Committee. Thus, as outlined in Fig 1 the Administrative Core A will 1: Fiscally Manage, Oversee, Facilitate and Evaluate Intra- Program Collaboration Among Projects & Cores; 2: Provide Infrastructure for Human Cohort Recruitment, Sample Collection, Tracking, & Sharing, 3: Develop Trans-SeroNet Collaborations and Collaborative Grants. As outlined in the Overview the UNC Center Research Program Team is already highly intellectually and technically integrated, building upon many multi-dimensional collaborations. As part of the Team structure, we have built layers with distinct yet complementary roles and responsibilities which will promote integrated experimental design, execution, and interpretation to address the current crisis and allow us to apply knowledge collaboratively. This will be supported by a Translational Services Initiative which thus has the infrastructure needed for recruiting sufficient patients and collecting samples necessary to support Projects 1-3 and Cores B and C. In addition, it will result in a bio/data repository in which samples that span the course natural disease, therapeutic interventions and potentially vaccination responses. In addition, our Program’s Annual Research Retreats and our SeroNet Collaborative Pilot and Feasibility Grant Mechanism will connect and integrate our Program, Projects and Cores with the broader SeroNet community further advancing research opportunities to characterize the immune responses elicited by SARS-CoV-2 viral infection.