Next Generation BiOactiVe NAnocoatings

Nova的目标是通过在涂层设计、最终用途和功能/安全测试之间建立有效的反馈循环，为抗菌涂层的开发提供一种全面的方法。这包括4种涂层技术的组合优化：i)基于UV上变频器、纳米光催化剂和疏水性碳基量子点的光激活；ii)接触式杀灭生物聚合物(多肽和多糖的链长受控的超分子组装)。涂层将在用例驱动的规范中进行调整，以使其能够在相同的环境(如医院)中为不同的基材涂层。为了保证公民和环境的安全，考虑到环境风险，将以安全和可持续的设计(SSBD)方法开发涂料。Nova将开发针对涂层进行优化的高级组织测试和免疫毒性测试，为监管机构提供工具，深入分析未来的涂层。为了展示实际效果，将开发模拟现实生活、创新的抗菌测试。经过验证的涂层将通过利用工业合作伙伴的能力扩大规模来开发用于商业开发。为便于采用，将在项目内设计特定的涂层应用装置。最后，项目内产生的实验数据以及该联盟涂层开发商的历史数据将用于开发使用机器学习方法的预测模型，以便在未来加快涂层开发方法。NOVA的目标是在四个主要用途(纺织品、油漆、触觉电子产品和经常接触的具有高度卫生相关性的硬表面，如医院和公共场所常见的卫生相关性)中展示的高效、环保、稳定的涂层，然后可以扩大到更广泛的使用。

NOVA aims to provide a comprehensive approach to antimicrobial coating development by creating an effective feedback loop between coating design, end use and functional/safety testing. This consists of combinatorial optimisation of 4 coating technologies: i) light activated based on: UV up-converters, nanoscale photocatalysts and hydrophobic carbon-based Quantum Dots and ii) contact killing biopolymers (chain-length controlled supramolecular assemblies of polypeptides and polysaccharides). The coatings will be adjusted in a use case driven specifications for having the capacity to coat different substrates in the same environment such as hospitals. In order to guarantee safety for citizens and environment, the coatings will be developed with a Safe and Sustainable by Design (SSbD) approach taking into account the environmental risks. NOVA will develop advanced tissue tests and immunotoxicity tests optimized for coatings to provide tools for the regulatory bodies an in depth analysis of future coatings. For demonstrating practical efficacy, real life mimicking, innovative antimicrobial tests will be developed. The validated coatings will be developed for commercial exploitation by upscaling using the capacities of the industrial partners. For easier adoption specific coating application devices will be designed within the project. Finally, the experimental data generated within the project together with the historical data of coating developers of the consortium will be used for developing predictive models using machine learning methodologies for expedited coating development methodologies in the future. NOVA aims to bring high efficiency, eco-friendly, stable coatings demonstrated within the project in 4 main use cases (textiles, paints, tactile electronics and frequently touched hard surfaces with high hygienical relevance like e.g. in hospitals and common hygienical relevance in public spaces) which can be then expanded for more widespread utilization.