Core B - Nonhuman Primates - Emory University

NHP CORE将利用埃默里耶基斯国家灵长类动物研究中心的NHP资源 Paiardini和Silvestri博士的具体专业知识下的大学-两个公认的领导人在研究 使用恒河猴（RM）S（H）IV感染模型的HIV发病机制和治疗-以促进 我们的P01项目1和2中包含的研究。NHP CORE的作用将包括（i）体内试验 在ART治疗的S（H）IV感染的RM中使用基于免疫的新型干预措施（FTY 720和bNAb）;（ii） 在所有体内研究中的纵向病毒载量定量;以及（iii）共享血液和组织 纵向采集的标本和尸检时与PI和项目的其他关键组成部分一起采集的标本。

The NHP CORE will leverage the NHP resources of the Yerkes National Primate Research Center of Emory University under the specific expertise of Drs. Paiardini and Silvestri - two well recognized leaders in studies of HIV pathogenesis and therapy using the model of S(H)IV infection of rhesus macaques (RMs) - to facilitate the studies included in Projects 1 and 2 of our P01. The role of the NHP CORE will include (i) the in vivo testing of novel immune-based interventions (FTY720 and bNAbs) in ART-treated S(H)IV-infected RMs; (ii) to perform the viral load quantifications longitudinally in all the in vivo studies; and (iii) sharing of blood and tissue specimens collected longitudinally and at necropsy with the PIs and the other key components of the program.