CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)
CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)
批准号:
10282192
负责人:
J VICTOR GARCIA-MARTINEZ
金额:
$290.77万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-30 至 2023-09-29
关键词:
BLT miceBloodCellsCommunicable DiseasesCommunitiesDevelopmentEnsureEpstein-Barr Virus InfectionsEvaluationHumanHuman Herpesvirus 4ImmuneImmune systemImmunologicsLongevityLymphoidLymphoid TissueMaintenanceMethodsModelingMusNeonatalNorth CarolinaOrganoidsPathologyReproducibilityStudy modelsThymus GlandTissuesTrainingUniversitiesgraft vs host diseaseimmune reconstitutionimprovedmembermouse modelreconstitution
中文摘要
来自查佩尔山的北卡罗来纳州大学的提案专注于使用新生组织构建人类免疫系统小鼠,并对优化的小鼠模型进行详细的免疫学分析。将进行研究以评价该模型对于爱泼斯坦巴尔病毒(EBV)和其他传染病的研究的适用性。
英文摘要
The proposal from the University of North Carolina at Chapel Hill focuses on constructing human immune system mice using neonatal tissue and conducting a detailed immunological analysis of the optimized mouse model. Studies will be done to evaluate the model’s suitability for the study of Epstein Barr virus (EBV) and other infectious diseases.
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