Cell factory of the future - scaling up culture of cells on bioemulsions

肉类生产占全球食品生产产生的温室气体排放量的60%，相当于每年排放175亿公吨。这与交通运输业的水平相当。仅替换20%的养殖肉类就意味着消除了7.6亿辆汽车产生的排放。为了喂养这些动物，必须清理土地供动物放牧和种植饲料。虽然越来越多的人变成素食主义者或纯素食主义者，但绝大多数人仍然不能在日常饮食中放弃肉类。在过去的十年中，养殖肉类（CM）行业已经增长。其精神是开发与养殖肉类无法区分的肉类，并通过减少土地使用和更可持续的生产流程帮助我们实现净零排放。然而，生物制造能力无法跟上。全球生物反应器的容量仅为1500万升，到2030年，估计需求将达到2.5亿升。虽然大多数CM行业都专注于通过细胞补料优化降低成本，但目前生物反应器和生物加工的局限性和效率低下往往被忽视。这些生物反应器中的大多数都是从细胞治疗行业改造而来的，在每个生物处理步骤中都有很大的损失，整个过程也是支离破碎的。因此，由于与养殖肉类相比，CM的种植成本很高，价格平价仍然难以实现。我们正在改变实验室中常规培养哺乳动物细胞的方式，将其培养在液滴表面，而不是固体基质（如微载体）上。该项目将专注于开发生物反应器，以补充我们已经开发的技术。这将使我们能够展示我们的技术所需的规模化能力和简化的生物加工。作为细胞制造平台，可以开发新类型的食品，提供更多的品种，并允许逐步从传统的肉类消费转变。通过加快产品开发，Liquibio有助于建立更具弹性的食品系统并降低二氧化碳排放。

Meat production accounts for 60% of greenhouse gas emissions generated by global food production, which translates to 17.5B metric tonnes of emissions per year. This is on par with those from transportation. Replacing just 20% of farmed meat translates to removing emissions generated by 760M cars. To feed these animals, land has to be cleared for animal grazing and growing their feed. While more people turn vegetarian or vegan, a large majority still cannot forego meat in their daily diets. In the past decade, the cultivated meat (CM) industry has grown. Its ethos is to develop meat that is indistinguishable from farmed meat and aid us in reaching net-zero emissions through reduced land usage and more sustainable production processes. However, biomanufacturing capacity cannot keep up. Global bioreactor capacity is only at 15 million litres and by 2030, it is estimated that the demand will be 250 million litres. While most of the CM industry is focusing on bringing down cost through cell feed optimisation, the limitations and inefficiencies of current bioreactors and bioprocessing is often overlooked. Most of these bioreactors are adapted from the cell therapy industry with great losses at every bioprocessing step and fragmented overall process. As a result, price parity is still difficult to achieve due to the high cost of growing CM compared to farmed meat.We are transforming how we routinely grow mammalian cells in the lab by growing them on the surface of liquid droplets rather than solid substrates such as microcarriers. This project will focus on developing a bioreactor to complement the technology we have developed. This will allow us to showcase the scale up capabilities and streamlined bioprocessing required with our technology.As a cell manufacturing platform, new types of food can be developed, giving more variety, and allowing the gradual shift from traditional meat consumption. By accelerating product development, Liquibio aids in building a more resilient food system and lowering CO2 emissions.