Neuromodulation of affective valence in humans by amygdala stimulation

项目摘要：刺激杏仁核对人类情感配价的神经调节 调查全球疾病负担的研究表明，在所有残疾中，有相当大比例- 由于不受控制的精神健康障碍，调整后的寿命年数会减少。适用于精神病患者 那些没有从传统的精神干预中受益的人，通过深部大脑进行神经调节 刺激疗法(DBS)是一种新兴的治疗方法。多条证据表明，大脑功能障碍 人类杏仁核在许多精神疾病的病理生理学中起着关键作用。 学期目标是确定人类杏仁核是否可以作为DBS治疗精神病的合适靶点。 精神错乱。此应用程序的主要目标是利用患者的机会 有用于癫痫的颅内电极来研究杏仁核如何处理情感配价 并确定针对杏仁核基底外侧核的电刺激是否安全 用于诱导价态感知和情感价态判断的神经网络的变化。 我们的中心假设是，电刺激杏仁核基底外侧核 情绪性配价感知任务的完成会改变配价的振荡特性 网络，进而改变患者在图片中感知情感价位的方式，而不会导致 刺激的不良副作用。我们认为，这种对认知的影响的诱导将对 未来对特定精神障碍治疗的影响，已知涉及 杏仁核。核心假设将通过追求两个具体目标来检验：(1)表征 价网络在价态判断中的振荡；(2)测量刺激的效果 杏仁核基底外侧核对价网络振荡特性的影响；以及(2B) 测量刺激杏仁核基底外侧核对情感配价知觉的影响。 对于目标1，我们记录和分析了在感知价态判断过程中的颅内脑电。 唤醒任务是为了更好地理解情感配价的振荡标记。为了达到这个目的 我们将使用抑制性刺激参数和颅内脑电来了解刺激是如何 杏仁核的基底外侧核影响神经网络的振荡特性 价的表示法。对于目标2B，我们将确定刺激如何影响感知和判断 价态。这项研究具有创新性，因为它使用了颅内脑电来了解神经 价的表示以及刺激如何影响神经网络和行为。建议数 这项研究意义重大，因为它将提高我们对价和 刺激参数对神经网络的影响。这项研究将为以下方面提供坚实的基础 杏仁核DBS在治疗特定精神疾病方面的未来发展。

PROJECT SUMMARY: Neuromodulation of affective valence in humans by amygdala stimulation Studies investigating global burden of disease have shown that a significant proportion of all disability- adjusted life years are lost due to uncontrolled mental health disorders. For patients with mental illness who have not benefited from conventional psychiatric interventions, neuromodulation via deep brain stimulation (DBS) is an emerging treatment option. Multiple lines of evidence show that dysfunction of the human amygdala plays a pivotal role in the pathophysiology of many psychiatric disorders The long- term goal is to determine if the human amygdala can be a suitable DBS target to treat psychiatric disorders. The main objective for this application is to take advantage of opportunity in patients who have intracranial electrodes for epilepsy to investigate how the amygdala processes affective valence and to determine if electrical stimulation targeted to the basolateral nucleus of the amygdala can be safely used to induce a change in neural network for valence perception and on judgment of affective valence. Our central hypothesis is that electrical stimulation of the basolateral nucleus of the amygdala during performance of an affective valence perception task will change the oscillatory properties of the valence network and in turn change how patients perceive affective valence in pictures without causing the undesirable side effects of stimulation. We propose that the induction of this effect on cognition will have future implications for the treatment of specific psychiatric disorders that are known to involve the amygdala. The central hypothesis will be tested by pursuing two specific aims: (1) Characterize oscillations of the valence network during judgment of valence; (2A) measure the effect of stimulation of the basolateral nucleus of the amygdala on the oscillatory properties of the valence network; and (2B) measure the effect of basolateral nucleus of the amygdala stimulation on perception of affective valence. For Aim 1, we record and analyze intracranial EEG during perception of the Judgment of Valence and Arousal Task to gain better understanding of the oscillatory markers of affective valence. For the Aim 2A, we will use inhibitory stimulation parameters and intracranial EEG to understand how stimulation of the basolateral nucleus of the amygdala affects the oscillatory properties of neural networks for representation of valence. For Aim 2B, we will determine how stimulation affects perception and judgment of valence. The research is innovative because it uses intracranial EEG to gain understanding of neural representation of valence and how stimulation effects neural networks and behavior. The proposed research is significant because it will improve our understanding of neural representation of valence and effect of stimulation parameters on neural network. The research will provide a strong foundation for future development of amygdala DBS for the treatment of specific psychiatric disorders.