Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core

摘要--生物医学信息学、生物信息学和网络基础设施 增强芯 临床和转化性研究的成功实施依赖于协调的访问、管理、 管理、保存、分析和传播来自多个来源的数据、信息和知识 (例如，学术、卫生和政府)。先进的CTR生物医学信息学的长期目标， 生物信息学和网络基础设施增强(BIBCE)的核心是改变临床环境 和罗德岛的翻译研究，通过支持访问电子健康数据，提供核心 信息学基础设施，并确定传播、实施和改进战略，以 克服将证据付诸实践的障碍。核心活动由布朗中心协调 生物医学信息学，以及Advance-CTR合作伙伴的领导(布朗大学、 罗德岛，寿命，关爱新英格兰，弗吉尼亚州普罗维登斯医疗系统，罗德岛州部门 和罗德岛质量研究所)。通过与我们的数据合作伙伴的正式安排，我们已经 克服访问和共享全州数据的障碍。BIBCE核心的下一阶段重点将是 将重点放在为标准化和综合接入建立可扩展的资源和服务上。定期参与 来自学术、卫生和政府社区的关键利益相关者的合作一直是BIBCE核心的关键 进一步加强资源和服务，促进可持续发展。核心还寻求培训和参与 研究人员应用资源、知识和技能来支持数据和技术的最佳实践- 推动基础、临床和人口科学领域的项目。BIBCE核心的使命是 从而促进数据和技术的使用，以支持全面的临床和转化性研究。 具体目标是：(1)促进可持续和可扩展的信息基础设施，以支持 临床和转化性研究需求的多样性；(2)开发创新数据、软件和技术 与临床和翻译研究人员合作的解决方案；以及，(3)提供最先进的信息学 与临床和转化性研究利益相关者进行培训和接触。BIBCE核心利用 以传播、实施和改进与我们的业务相关的解决方案 当地社区，并仍可在全国范围内推广。成功转型和振兴临床和医疗服务的标准 翻译研究与生物医学信息学定义的国家评估标准保持一致 社区。以RE-AIM(覆盖范围、有效性、采用、实施和维护)为指导 框架，并与跟踪和评价核心合作，我们将评价这些成果、影响、 和衡量进展和成功实现总体进步-CTR目标的指标，包括我们州的 健康优先事项。Advance-CTR合作伙伴继续参与使用数据和 改善该州和地区人口健康的技术将协同扩大临床和 翻译研究机会。

ABSTRACT – BIOMEDICAL INFORMATICS, BIOINFORMATICS, AND CYBERINFRASTRUCTURE ENHANCEMENT CORE The successful execution of clinical and translational research relies on coordinated access, curation, management, preservation, analysis, and dissemination of data, information, and knowledge from many sources (e.g., academic, health, and government). The long-term goal of the Advance-CTR Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement (BIBCE) Core is to transform the environment for clinical and translational research in Rhode Island by enabling access to electronic health data, providing core informatics infrastructure, and identifying dissemination, implementation, and improvement strategies to overcome barriers to adoption of evidence into practice. Core activities are coordinated by the Brown Center for Biomedical Informatics, along with leadership from Advance-CTR partners (Brown University, The University of Rhode Island, Lifespan, Care New England, VA Providence Healthcare System, the Rhode Island Department of Health, and the Rhode Island Quality Institute). Through formal arrangements with our data partners, we have overcome barriers to accessing and sharing statewide data. The focus of the next phase of the BIBCE Core will be on establishing scalable resources and services for standardized and integrated access. Regular engagement of key stakeholders from the academic, health, and government communities has been critical as BIBCE Core resources and services are further enhanced to promote sustainability. The Core also seeks to train and engage researchers in best practices for applying resources, knowledge, and skills to support data- and technology- driven projects across the spectrum of basic, clinical, and population science. The mission of the BIBCE Core is thus to advance use of data and technology to support the full spectrum of clinical and translational research. The Specific Aims are to: (1) Promote a sustainable and extensible informatics infrastructure to support the diversity of clinical and translational research needs; (2) Develop innovative data, software, and technology solutions in collaboration with clinical and translational researchers; and, (3) Provide state-of-the-art informatics training and engagement with clinical and translational research stakeholders. The BIBCE Core capitalizes on the diverse population of Rhode Island to disseminate, implement, and improve solutions that are relevant to our local community, and still be scaled nationally. Metrics for success to transform and invigorate clinical and translational research are aligned with national standards for evaluation as defined by the biomedical informatics community. Guided by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework and in collaboration with the Tracking and Evaluation Core, we will evaluate these outcomes, impacts, and metrics to gauge progress and success in meeting overall Advance-CTR objectives, including for our state’s health priorities. The continued engagement of Advance-CTR partners with the shared vision of using data and technology to improve the health of the State’s and regional population will synergistically expand clinical and translational research opportunities.