Pilot and Exploratory Core PESC

PESC摘要/摘要 试点和探索性研究核心(PESC)将促进开发新的想法和方法，以 通过精准老年学改善和维持老年人的独立功能。使用严格的 为最大限度地提高研究人员追求精确度的渠道而开发的申请和选择程序 在老年学方面，PESC每年将选出最多3项试点和探索性研究(PES)。选择 申请申请(RFA)中规定的标准将包括可能导致更大的高影响 项目，胡椒核心的参与，以及对康涅狄格州大学胡椒中心的响应专注于精确度 老年学。PESC资助的项目可以包括从基本工作台到人体受试者的一系列研究设计 从研究到人口科学。PESC寻求在第一年资助三个(PES)，每个都强调增强 了解老化的异质性和/或改善老化的靶向性。PES1，冷漠：早期 老年抑郁症患者的虚弱和残疾的表现将检验以下假说 老年抑郁症患者和老年抑郁症患者的功能表现和血液生物标志物的差异 没有冷漠。这项研究的结果将加深对冷漠和 可能有助于确定老年抑郁症患者的治疗目标。PES2，多组件基于网络的行为 干预措施改善非洲裔美国老年人的身体功能和其他健康结果 新冠肺炎时代，将开发、实施和评估一种多元的、根据文化定制的教育 干预措施，以重新参与和促进非洲人的体力活动、充足的营养和最佳的心理健康 美国老年人。PES3，老龄化队列中脆弱性的异质性(HVAC)：一种新的资源 早期生物标记物的发现和验证，旨在为初级教员提供：(1)准备IRB的经验 协议、招募人类受试者和评估脆弱性；以及(2)生成数据的机会 用于开发生物标记物发现和未来NIH拨款申请的平台。这些目标将是 使用与特定类型相关的明确定义的老年临床表型的队列来完成 脆弱的脆弱的或脆弱的每个PES的成功衡量标准将包括生成初步数据以支持 美国国立卫生研究院的外部赠款申请和通过演示文稿和手稿传播知识。总括 PESC核心的成功将通过对RFA的响应和同行审查的数量来评估 由PESC资助的研究产生的手稿、提交的申请和外部资金。

PESC ABSTRACT/SUMMARY The Pilot and Exploratory Studies Core (PESC) will promote the development of novel ideas and approaches to improving and sustaining independent function in older persons through Precision Gerontology. Using a rigorous application and selection process developed to maximize the pipeline of investigators pursuing Precision Gerontology, the PESC will select up to 3 pilot and exploratory studies (PES) each year of the award. Selection criteria specified in the Request for Applications (RFA) will include the potential to lead to larger high-impact projects, involvement of Pepper Cores, and responsiveness to the UConn Pepper Center focus on Precision Gerontology. PESC-funded projects can include a range of study designs from basic bench and human subject research to population science. The PESC seeks to fund three(PES) in Year 1 that each emphasize enhanced understanding of heterogeneity with aging and/or improved targeting in aging. PES1, Apathy: An Early Manifestation of Frailty and Disability in Older Adults with Depression?, will test the hypotheses that there will be differences in functional performance and blood-based biomarkers between older depressed adults with and without apathy. The results of this study will enhance understanding the pathophysiology underlying apathy and may help identify treatment targets in older depressed adults. PES2, Multicomponent web-based behavioral intervention to improve physical function and other health outcomes among African American older adults in the COVID-19 era, will develop, implement, and evaluate a multicomponent, culturally-tailored educational intervention to reengage and promote physical activity, adequate nutrition, and optimal mental health for African American older adults. PES3, The Heterogeneity of Vulnerabilities in Aging Cohort (HVAC): A new resource for early biomarker discovery and validation, seeks to provide junior faculty with: (1) experience in preparing an IRB protocol, recruiting human subjects, and assessing frailty; and (2) the opportunity to generate data that can be used to develop a platform for biomarker discovery and for future NIH grant applications. These goals will be accomplished using a cohort of well-defined geriatric clinical phenotypes that are associated with particular types of vulnerability or frailty. Metrics of success for each PES will include generation of preliminary data to support external NIH grant applications and dissemination of knowledge via presentations and manuscripts. Overall success of the PESC Core will be assessed in terms of responsiveness to the RFA and number of peer-reviewed manuscripts, submitted applications, and external funding generated from PESC-funded studies.