Biomarkers Core RC3

RC3项目摘要 RC3生物标志物和临床前核心的目标是为康涅狄格州大学胡椒中心(OAIC)的学员、飞行员 和发展项目调查员以及拥有所需专业知识和工具的更广泛的科学界 询问生物标记物，衰老的驱动因素和人类慢性病的潜在机制 动物模型，以促进晚年的功能和独立性。由RC3支持的研究将 通过强调源自精确老年学的方法来推进这些康涅狄格州大学的OAIC目标，我们的主题 全神贯注。为此，RC3将强调能够定义生物学的方法和技术 异质性可以导致生物标记物的发现和改善干预的靶向性。RC3 将为调查人员提供指导，协调访问现有的康涅狄格州健康和杰克逊实验室核心和 资源。对于对具体方法缺乏深入了解的调查人员，将提供建议和帮助 在项目开发方面，为其拟议的研究确定最佳方法、分析和分析。 RC3还将为所有参与康涅狄格州大学OAIC研究的人类受试者提供生物标志物分析。这个 具体目标是：(1)协助研究人员制定涉及生物标记物的实验方案 老龄化和相关条件，如慢性病、复原力、虚弱和残疾，以实现以下目标 每个项目；(2)促进调查人员、已建立的核心设施和RC2数据资源之间的互动 核心，以实现在每个项目中评价生物异质性的目标；(3)开发 生物库和生物标记物的发现。

RC3 Project Summary The goal of the RC3 Biomarkers and Preclinical Core is to provide UConn Pepper Center (OAIC) trainees, pilot and developmental project investigators and the broader scientific community with expertise and tools needed to interrogate biomarkers, drivers of aging and underlying mechanisms of chronic diseases in humans and animal models in order to promote function and independence in late life. Research supported by RC3 will advance these UConn OAIC goals by emphasizing approaches derived from precision gerontology, our thematic focus. To that end, RC3 will emphasize approaches and technologies capable of defining biological heterogeneity in a manner that can lead to biomarker discovery and improved targeting of interventions. RC3 will offer investigators guidance with coordinated access to existing UConn Health and Jackson Lab cores and resources. For investigators lacking deep familiarity with specific methods, advice and assistance will be offered in terms of project development to determine best approaches, assays and analyses for their proposed studies. RC3 will also provide biomarker analysis for all human subjects who participate in UConn OAIC studies. The Specific Aims are: (1) Assist investigators in the development of experimental protocols involving biomarkers of aging and related conditions such as chronic diseases, resilience, frailty and disability to achieve the goals of each project; (2) Facilitate interaction between investigators, established core facilities and RC2 Data Resource Core in order to achieve the goals for evaluating biological heterogeneity in each project; (3) Development of a biobank and biomarker discovery.