Pilot/Exploratory Studies Core (PESC)

项目摘要--试点和探索性研究核心(PESC) PESC的总体目标是进行试点研究，为选择、设计和实施 随后在杜克大学OAIC主题中进行了更大规模的假设检验研究，以了解和优化储备 和恢复力。PESC支持在细胞、组织、器官和个体水平上的生理储备研究 因为每个人都是理解和支持整个人层面上的韧性的关键贡献者。而当 该核心支持在干预阶段之前所需的关键的、与复原力相关的试点工作(例如， 措施或模式系统的发展)、PESC指导方法和伊斯兰会议组织环境培训 获奖者设想并制定他们的研究路线将如何转化为改善人类成果的战略。 PESC的具体目标是(1)促进与晚年储备相关的高质量科学和 坚韧不拔；(2)吸引和培养一支多元化的优秀调查人员队伍，有能力追求有前途的事业 与我们的主题相关的老龄化研究的新方向；(3)与关键人物建立和保持关系 让利益攸关方最大限度地发挥通过PESC开展的工作的影响和转化。要完成 为了实现这些目标，PESC与其他OAIC核心广泛合作，为 获奖者(研究教育部分[REC])，协调广泛的征集和遴选过程，以 吸引和培养来自广泛调查人员(领导力和 管理核心[LAC])，并支持单个项目需求(分子测量核心[MMC]，健康 和移动性测量核心[HMC]和分析核心[AC])。PESC还利用机构 资源包括杜克临床和转化科学研究所(CTSI)、杜克老龄中心、 杜克·罗伊巴尔中心和杜克·REACH股权中心。此外，PESC还与外部利益相关者接洽 杜克大学，包括社区代表和为项目做出贡献的外部审查员 选拔以及老化的研究网络，以进一步奖励获奖者的职业发展机会和 科学影响和翻译。PESC每年将支持至少三个项目，利用 提供机构资金，支持更多高水平的试点项目或规模较小的“种子”奖项。指标 成功包括实现个别项目里程碑；传播成果(专题介绍、 出版物)；资助调查人员队伍的多样性；利用试点数据为更大规模的、 假设检验研究。

PROJECT SUMMARY – PILOT AND EXPLORATORY STUDIES CORE (PESC) The overall objective of the PESC is to conduct pilot studies that inform the selection, design, and conduct of subsequent larger, hypothesis-testing research in the Duke OAIC theme ‘to understand and optimize reserve and resilience’. The PESC supports studies of physiological reserve at cell, tissue, organ, and individual levels because each are key contributors to understanding and bolstering resilience at the whole person level. While this Core supports the crucial, resilience-related pilot work that is needed prior to the stage of intervention (e.g., development of measures or model systems), the PESC mentoring approach and OAIC environment trains awardees to envision and strategize how their line of research will translate into improved human outcomes. The Specific Aims of the PESC are (1) to advance top quality science related to late-life reserve and resilience; (2) to attract and nurture a diverse cadre of outstanding investigators equipped to pursue promising new directions in aging research related to our theme; (3) to build and sustain relationships with critical stakeholders to maximize the impact and translation of the work conducted through the PESC. To accomplish these Aims, the PESC partners extensively with other OAIC Cores to extend mentorship and training for awardees (Research Education Component [REC]), to coordinate a broad solicitation and selection process to attract and cultivate highly meritorious applications from a wide range of investigators (Leadership and Administrative Core [LAC]), and to support individual project needs (Molecular Measures Core [MMC], Health and Mobility Measures Core [HMC], and Analysis Core [AC]). The PESC also leverages institutional resources including the Duke Clinical and Translational Science Institute (CTSI), the Duke Aging Center, the Duke Roybal Center, and the Duke REACH Equity Center. Further, the PESC engages stakeholders outside of Duke University, including community representatives and external reviewers who contribute to project selection as well as aging research networks that further awardees’ opportunities for career development and scientific impact and translation. The PESC will support at least three projects each year, leveraging institutional funding to support additional high caliber pilot projects or smaller-scale “seed” awards. Metrics of success include attainment of individual project milestones; dissemination of results (presentations, publications); diversity of the cadre of funded investigators; and use of pilot data to obtain funding for larger, hypothesis-testing studies.