Molecular mechanisms determining the lipid composition of synapses

神经元之间的突触在神经系统的所有功能中起着关键作用，包括学习和记忆。它们主要由蛋白质和脂质的独特组合组成，它们共同起作用，使神经传递成为可能。虽然确定突触蛋白质组成的分子机制已经被很好地表征，但确定突触脂质组成的机制仍然未知。该项目将使用神经科学和脂质研究的先进技术来确定突触中脂质运输和保留的机制。该项目有望产生关于大脑功能基本机制的新知识，这将有助于开发增强脑力的新疗法。

Synapses between neurons play a key role in all functions of the nervous system including learning and memory. They are mostly composed of the unique combination of proteins and lipids, which function together to enable neurotransmission. While the molecular mechanisms determining the protein composition of synapses are well characterised, the mechanisms defining the lipid composition of synapses remain unknown. The project will use advanced techniques of neuroscience and lipid research to determine the mechanisms of lipid transport and retention at synapses. The project is expected to generate new knowledge about the fundamental mechanisms of brain function, which will be useful for developing new therapeutics enhancing the brain power.