1/2 CSUF/UCI-CFCCC Cancer Health Disparities Research Program (CHERP)

CSUF/UCI-CFCCC癌症健康公平研究伙伴关系(CHEP) 整体组件：摘要 加州州立大学富勒顿分校(CSUF)是一所为服务不足的人群提供服务的机构 代表不足的学生(ISUPS)和加州大学欧文·赵家族综合癌症 UCI-CFCCC是美国国家癌症研究所指定的综合性癌症中心。我们计划共同建立一个 合作伙伴关系，在CSUF和UCI-CFCCC的教职员工之间开发试点研究项目 这将为R01或其他竞争对手资助的赠款申请生成初步数据，并教育 癌症健康差异研究的本科生(CSUF)和硕士学生(CSUF和UCI)。这个 伙伴关系计划资助五个试点项目，并在拟议的期间总共教育38名学生 授权期。这一新的针对癌症的伙伴关系的总体具体目标是：计划、实施和 评估CSUF和UCI之间高度整合和互动的癌症健康差异合作伙伴关系- 开展癌症健康差异试点研究项目，每个项目至少有一名研究人员参与 促进关于癌症健康差异的知识的机构，导致提交竞争对手 资助NIH/NCI和其他联邦/非联邦机构的申请；并提供癌症研究教育 面向未被充分代表的本科生和研究生，以增加他们对癌症健康的了解 这种差异导致了更多来自不同背景、才华横溢的未来科学家。 为实现这一目标，我们将开展一系列按四个组成部分组织的活动。行政部门 核心将负责所有P20活动的总体行政和财政方面，并将包括 执行委员会和内部咨询委员会。活动将分三个阶段实施：初期 规划、实施和评估。评估工作将由一名外部评估员带头进行 具有多组件中心评审方面的专业知识。这两个试点研究项目的重点都是癌症健康。 差异：第一项是基础科学研究，将进行脂肪组学分析，以及DNA和RNA测序 Tumor/NAT配对样本以优化样本准备并检测遗传/基因组和转录 与非裔美国人三重负乳腺癌风险相关的差异。第二个是一个 一项流行病学研究，将考察亚洲亚种族群体在卵巢癌死亡率和 治疗模式。这一合作伙伴关系的长期目标是使癌症研究多样化 并最终增加我们的科学影响力，以解决橙色地区癌症健康差距的需求 加利福尼亚州的县。

CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP) Overall Component: Abstract California State University, Fullerton (CSUF) is an institution serving underserved populations and underrepresented students (ISUPS), and the University of California, Irvine Chao Family Comprehensive Cancer Center (UCI-CFCCC) is an NCI-designated comprehensive cancer center. Together, we plan to establish a collaborative partnership to develop pilot research projects between faculty members at CSUF and UCI-CFCCC that will generate preliminary data for R01 or other competitively funded grant applications, and educate undergraduates (at CSUF) and master's students (at CSUF and UCI) in cancer health disparities research. The Partnership plans to fund five pilot projects, and educate a total of 38 students during the length of the proposed grant period. The overall specific aims of this new cancer-specific partnership are to: plan, implement and evaluate a highly integrated and interactive cancer health disparities partnership between CSUF and UCI- CFCCC; conduct pilot cancer health disparities research projects involving at least one investigator at each institution that advance knowledge regarding cancer health disparities, leading to the submission of competitive grant applications by NIH/NCI and other federal/non-federal agencies; and provide cancer research education to underrepresented undergraduate and graduate students to increase their understanding of cancer health disparities, leading to a larger pool of highly talented future scientists from diverse backgrounds. To accomplish this we will undertake a set of activities organized under four components. The Administrative Core will be responsible for the overall administrative and fiscal aspects of all P20 activities, and will include the Executive Committee and Internal Advisory Committee. Activities will be implemented in three stages: initial planning, implementation, and evaluation. The evaluation effort will be spearheaded by an external evaluator with expertise in multi-component center reviews. The two pilot research projects each focus on a cancer health disparity: the first is a basic science study that will conduct lipidomic profiling, and DNA and RNA sequencing of tumor/NAT paired samples to optimize sample preparation and detect genetic/genomic and transcriptomic differences that are related to African American triple negative breast cancer risk. The second is an epidemiological study that will examine Asian sub-ethnic group differences in ovarian cancer mortality and treatment patterns. The long term goals of this collaborative partnership are to diversity the cancer research workforce and ultimately increase our scientific impact to address the cancer health disparity needs in Orange County, California.