Mechanisms of memory integration in brain systems

从我们与环境的相互作用中学习是大脑最重要的功能之一，但这一过程在神经网络层面如何以及在何处发生已被证明难以建立。本项目旨在研究大脑中的主要神经调节信号如何协调大型神经元集合中基于奖励的学习的编码。这些研究将把联合收割机新的行为范例与最新的神经科学技术结合起来，用于对行为小鼠的特定神经回路进行功能映射和操纵。这项研究的结果将导致我们对大脑系统中学习整合机制及其对行为影响的理解发生重大转变。

Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuroscience techniques for functional mapping and manipulation of specific neural circuits in behaving mice. The outcomes of this research will lead to a significant shift in our understanding of the mechanisms underpinning the integration of learning in brain systems and its implications for behaviour.