Administrative Core

摘要 结核病（TB）是全球单一传染性病原体导致死亡的主要原因， 艾滋病毒/艾滋病造成的死亡总数的三分之一。了解酒精在新发结核病感染中的作用， 活动性结核病的发生，以及结核病治疗后的肺部疾病对艾滋病毒感染至关重要， 降低艾滋病毒携带者中结核病发病率和死亡率的风险。国际乌干达俄罗斯的主题 波士顿酒精网络艾滋病毒/艾滋病酒精研究合作中心（URBAN AIDSCenter） 了解酒精对艾滋病毒携带者结核病感染谱的影响。国际城市 艾滋病中心将继续利用其在建立和维持艾滋病毒携带者队列方面的经验， 乌干达和俄罗斯，并将评估在这些地方独特的研究问题。这一全球 研究与NIH艾滋病研究办公室对艾滋病毒和艾滋病毒相关研究的最高优先级保持一致 (i.e.,解决HIV相关的合并症、合并感染和并发症）。行政（Admin） 核心将为国际城市规划中心提供组织框架，并将促进 中心4个组成部分之间的协同作用：1）管理核心; 2）生物统计和数据管理（BDM） 核心项目; 3）俄罗斯项目; 4）乌干达项目。管理核心将负责日常工作， 中心的管理和运作，目标是确保科学和方案 该中心的活动得到整合，并以高质量和及时的方式开展。管理核心将 实现以下具体目标：1）促进合作，协同研究目标的方法; 2） 促进所有中心组件之间的沟通、集成和协作; 3）协调访问 资源，包括国际城市监测中心数据和样本储存库; 4）评估和 促进各组成部分的进步和质量，以最大限度地发挥中心的科学影响; 5）鼓励 与中心内外的研究者共享数据;以及6）培养中心未来的领导力 和下一代的艾滋病毒/酒精研究人员。在管理核心的领导下， 促进和研究管理，国际城市规划中心将产生新的概括 了解结核病、艾滋病毒和饮酒之间的复杂关系，以加速未来 制定干预措施，减少酒精对结核病相关发病率和死亡率的影响， PLWH。国际城市规划中心的成功关键取决于管理核心的 科学和行政领导，以确保所有组成部分以最佳方式发挥协同作用。

ABSTRACT Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide, and accounts for a third of the total number of deaths caused by HIV/AIDS. Understanding the role of alcohol in new TB infection, occurrence of active TB disease, and lung disease after TB treatment in the context of HIV infection is vital to reducing the risks of TB morbidity and mortality among PLWH. The theme of the International Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center is to understand the impact of alcohol on the spectrum of TB infection among PLWH. The International URBAN ARCH Center will continue to build on its experience in establishing and maintaining cohorts of PLWH in Uganda and Russia and will evaluate research questions uniquely addressable in these locations. This global research is aligned with the NIH Office of AIDS Research’s highest priorities for HIV and HIV-related research (i.e., addressing HIV-associated comorbidities, coinfections, and complications). The Administrative (Admin) Core will provide the organizational framework for the International URBAN ARCH Center and will facilitate synergy among the Center’s 4 components: 1) Admin Core; 2) Biostatistics and Data Management (BDM) Core; 3) Russia Project; and 4) Uganda Project. The Admin Core will be responsible for day-to-day management and functioning of the Center with the goal of ensuring that the scientific and programmatic activities of the Center are integrated and carried out with high quality and timeliness. The Admin Core will accomplish the following Specific Aims: 1) Promote a collaborative, synergistic approach to research goals; 2) Facilitate communication, integration, and collaboration between all Center components; 3) Coordinate access to resources including the International URBAN ARCH Center data and sample repository; 4) Assess and foster components’ progress and quality to maximize the scientific impact of the Center; 5) Encourage the sharing of data with investigators within the Center and beyond; and 6) Develop future leadership of the Center and the next generation of HIV/alcohol researchers. Under the leadership of the Admin Core and with its expert facilitation and research management, the International URBAN ARCH Center will generate new generalizable knowledge about the complex relationship between TB, HIV, and alcohol use in order to accelerate the future development of interventions that can reduce alcohol’s impact on TB-related morbidity and mortality among PLWH. The success of the International URBAN ARCH Center is critically dependent on the Admin Core’s scientific and administrative leadership to ensure that all components function optimally and synergistically.