Fast and accurate self-monitoring tests for better adherence to exercise and diet

生活方式疾病是由于长期暴露于主要由三种可避免的行为造成的健康风险而引起的：吸烟、不健康饮食和缺乏身体活动。中风、糖尿病、心脏病发作或肺癌等疾病会导致个人生活质量下降，但也会导致相当一部分死亡，并造成巨大的医疗和经济成本。尽管这些潜在的行为是完全可以避免的，但许多人发现很难甚至不可能改变它们。造成这一困难的原因之一在于长期性换句话说，缺乏的是一个及时的（几小时到几天）积极和激励性的反馈循环，以看到行为改变的效果。例如，改变不健康的饮食习惯通常不会导致几个月的显着减肥（忽略潜在的不健康的速成饮食）。同样地，开始一个锻炼计划在很长一段时间内不会对体格、力量或有氧健身产生显著的改善（取决于所选择的锻炼以及强度和持续时间）。本项目将使用已发表的关于血液和唾液中分子的知识，这些分子可以反映身体在营养和锻炼方面的状态。其中一种生物标志物在莫斯利博士的关于禁食饮食的地平线纪录片中得到了突出的应用（[https：//www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0]）。该项目将使用已经确定的检测试剂，这些试剂只需要适应自我管理的侧向流测试（LFT），我们在大流行期间都必须熟悉这种测试。预期的结果易于使用和解释LFT，它可以在开始节食或运动后的几小时到几天内测量对身体的影响。结果可以用来庆祝成功的生活方式改变之前，体重或健身的变化可以衡量。疫情后，定制LFT制造变得更便宜，因此我们的LFT产品可以变得非常实惠。但是，即使是对拟议中的测试的微小吸收，以提高生活方式改变的成功率，也会对个人，社会和英国财政产生巨大的积极影响-考虑到20%的人口被归类为肥胖，每年超过100万的住院人数（2020年NHS数据）与肥胖有关。[0]：https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer网站

Lifestyle diseases arise through prolonged exposure to health risks caused by mainly three avoidable behaviours: smoking, unhealthy diet, and physical inactivity. Resulting illnesses, such as stroke, diabetes, heart attack, or lung cancer result in a loss of quality of life for the individual, but also in a significant portion of all deaths and huge healthcare and economic costs.Despite the underlying behaviours being entirely avoidable, many individuals find changing them hard or even impossible. One of the reasons for this difficulty lies in the long-term nature (months to years) of health improvements to manifest themselves, in other words, what is missing is a timely (hours to days) positive and motivating feedback loop to see the effects of behavioural change efforts.Changing unhealthy eating habits, for example, will not normally result in significant weight loss for several months (ignoring potentially unhealthy crash diets). Similarly, starting a regime of exercises will not yield significant improvements to either physique, strength, or aerobic fitness for a long time (depending on the exercises chosen and the intensity and duration of them).This project will use published knowledge about molecules in blood and saliva, which can reflect the state of the body with respect to nutrition and exercise. One such biomarker was prominently used in Dr Mosley's Horizon documentary on fasting diets ([https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer][0])The project will use already identified detection reagents that only need adaptation to function in self-administered Lateral Flow Test (LFT) with which we all had to become familiar during the pandemic. The anticipated results are easy to use and interpret LFTs which can measure the effect on the body in hours to a few days after starting a diet or an exercise regime. Results can be used to celebrate successful lifestyle change long before changes to weight or fitness could be measured. They can also be used to optimize and compare different diets or exercises, greatly adding to the empowerment of individuals regarding their lifestyle changes.After the pandemic, custom LFT manufacturing became much cheaper and our LFT products can therefore be made very affordable. But even a minor uptake of the proposed tests to improve the success of lifestyle changes would have an enormously positive effect on individuals, society, and UK finances - given that 20% of the population is classified as obese and that over 1 million hospital admissions per year (2020 NHS data) were related to obesity.[0]: https://www.bbc.co.uk/iplayer/episode/b01lxyzc/horizon-20122013-3-eat-fast-and-live-longer