Role of Sulfiredoxin in Colorectal Cancer Development

结直肠癌是第三大最常见的诊断癌症和第二大癌症死亡原因 在美国和全世界的男性和女性中。结直肠癌死亡的主要原因之一是由于 癌细胞从原发肿瘤部位扩散到远处器官，这一过程称为癌细胞扩散。 侵袭和转移。这一过程是由各种生物分子及其 相关的信号通路。我研究的长期目标是了解结肠肿瘤的发生 和转移过程，并了解其功能机制， 发展有效的癌症靶向治疗方法。Sulfiredoxin是一种新的氧化还原酶， 促进大肠癌的发生和转移。在这个项目中，我们的目标是 了解硫氧还蛋白促进癌细胞侵袭和转移的分子机制， 测试Srx的新型小分子抑制剂在阻断人结肠直肠癌侵袭中的功效， 转移使用细胞培养以及小鼠模型。

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in USA and worldwide. One of the major causes of colorectal cancer mortality is due to the spreading of cancer cells from primary tumor sites to distant organs, a process known as cancer cell invasion and metastasis. This process is coordinately regulated by various biological molecules and their associated signaling pathways. The long-term objective of my research is to understand colon tumorigenesis and metastatic process by identifying critical molecular drivers, and to understand their function mechanisms to develope effective ways for targeted cancer therapy. Sulfiredoxin is a novel redox enzyme that has a critical role of promoting tumorigenesis and metastasis of colorectal cancer. In this project, our goals are to understand molecular mechanisms by which Sulfiredoxin promotes cancer cell invasion and metastasis, and to test the efficacy of a novel small molecule inhibitor of Srx in blocking human colorectal cancer invasion and metastasis using cell culture as well as mouse models.