Annual Vitamin D Workshops

维生素D工作坊是一个非营利性的教育组织(Est.1977)，其任务是组织 关于维生素D的新陈代谢、生物功能和对健康影响的科学会议。 资助申请，以支持2021-2025年间的一系列年度维生素D研讨会。到目前为止已经有 22个非常成功的国际维生素D研讨会，通常吸引了200-300名基础 来自全球各地的研究人员、转化型科学家、临床医生和政策制定者。维生素D是 激活核受体(维生素D受体，或VDR)的活性类固醇激素的前体 调控基因表达。它的传统作用是调节骨骼、肾脏和肠道细胞的生物学。 控制钙和骨代谢。维生素D可以通过饮食和维生素补充剂获得 D2和D3，以及维生素D3在皮肤暴露在紫外线下也可以合成。既有护肤产品，又有 维生素D和控制钙代谢的分子作用因衰老而受到抑制。许多研究 具有与多种生理和年龄相关的病理过程相关的维生素D状态，例如 癌症、糖尿病、多发性硬化症和炎症性肠病。虽然这项研究已经产生了 媒体的大量关注，也引发了许多关于维生素分子作用的新问题 D激素、评估维生素D状况的挑战以及预防慢性病的最佳摄入量。它 目前尚不清楚年龄、种族和基因如何影响维生素D的作用，以及维生素D的需求是如何改变的 不同的人群。这些问题引起了科学家、卫生专业人员和公众的极大兴趣。 总而言之，这些因素证明了维生素D科学家的年度会议是合理的，以分享研究想法和 资源，讨论新出现的基础和应用数据，并揭示有争议的领域。 维生素D研讨会的具体目标是： 1.举办一系列关于维生素D的生物学和与健康相关的应用的科学会议 地址： ·关于苯丙氨酸的生产、代谢和机制的最新同行评议的科学研究 维生素D的作用与生理状态和年龄有关。 ·关注全世界各年龄段的维生素D缺乏症，以及如何最好地识别、治疗 并在不同的人群和年龄段预防这种情况。 ·个人维生素D摄入量和补充剂的充足和安全水平的证据 在整个生命过程中，以及那些患有各种与年龄相关的慢性病的人中。 ·研究维生素D的最新研究方法。 2.汇聚来自学术界、医学界、工业界、政府和 在科学检查维生素D对健康的影响方面有共同利益的基层组织 3.鼓励和表彰早期、少数族裔和弱势群体的研究人员 维生素D并通过提供奖学金、旅行和促进他们与知名研究人员的互动 资助金和青年调查员奖。 4.通过出版会议记录来传播研讨会的成果。

The Vitamin D Workshop is a non-profit educational organization (est. 1977) whose mission is to organize scientific meetings on the metabolism, biological functions, and health effects of vitamin D. The goal of this R13 grant application to support a series of annual Vitamin D Workshops from 2021-2025. To date there have been 22 highly successful international Vitamin D Workshops which have typically attracted 200-300 basic researchers, translational scientists, clinicians, and policy makers from around the globe. Vitamin D is the precursor for an active steroid hormone that activates a nuclear receptor (the Vitamin D receptor, or VDR) to regulate gene expression. Its traditional role is to regulate the biology of cells in the bone, kidney, and intestine to control calcium and bone metabolism. Vitamin D can be obtained through diet and supplements as vitamins D2 and D3, and vitamin D3 can also be synthesized in skin upon exposure to UV light. Both the skin production of vitamin D and the molecular actions controlling calcium metabolism are suppressed by aging. Many studies have associated vitamin D status with a wide variety of physiologic and age-related, pathologic processes, e.g. cancer, diabetes, multiple sclerosis, and inflammatory bowel disease. While this research has generated considerable media attention, it has also led to many new questions about the molecular actions of the vitamin D hormone, the challenges of assessing vitamin D status and the optimal intake to prevent chronic diseases. It is not clear how aging, ethnicity and genetics influence vitamin D actions, and how requirements are altered in diverse populations. These issues are of great interest to scientists, health professionals and the general public. Collectively, these factors justify an annual meeting of vitamin D scientists to share research ideas and resources, discuss the emerging basic and applied data, and bring areas of controversy to light. The Specific Aims of the Vitamin D Workshops are: 1. To conduct a series of scientific conferences on the biology and health-relevant applications of vitamin D that address: • The latest peer-reviewed scientific research regarding the production, metabolism and mechanisms of action of vitamin D as they relate to physiologic state and age. • The concern of worldwide vitamin D deficiency across age groups as well as how to best identify, treat and prevent this condition in different populations and age groups. • The evidence on the adequate and safe levels of vitamin D intake and supplementation for individuals throughout the life course and in those with various age-related chronic disease states. • State of the art research approaches for studying vitamin D. 2. To bring together an interdisciplinary group of scientists from academia, medicine, industry, government and grassroots organizations with common interests in scientifically examining the health effects of vitamin D. 3. To encourage and recognize early-stage, minority and disadvantaged investigators conducting research on vitamin D and facilitate their interactions with established investigators through provision of scholarships, travel grants and young investigator awards. 4. To disseminate outcomes of the workshop through publication of the Conference Proceedings.