Shared Resource: Translational BioImaging

项目摘要：翻译生物成像核心共享资源(TBICSR) 体内成像生物标记物已成为癌症研究中不可或缺的一部分。翻译型生物成像核心 共享资源(TBICSR)为弗雷德·哈奇/华盛顿大学提供各种成像资源和支持 华盛顿癌症联盟通过跨学科共享资源的跨学科运作进行研究 机构。TBICSR的目标是使最广泛的高端成像资源可用于 以具有成本效益和效率的方式为财团成员提供服务。TBICSR通过实现一个 影像资源(和专业知识)的共享使用模式。这是一种最具成本效益的方法 无论单个站点的使用量如何，联盟成员均可使用的成像资源范围。 通过允许熟练用户通过在线计划访问设备来实现制定研究的效率 还为寻求成像建议的潜在调查人员提供咨询服务 选择。当需要咨询时，成像专家可以协助机构动物护理 和使用委员会(IACUC)编写，必要时安排机构间交通和住房， 和系统调度。通过院系成像进一步支持成像资源的优化 与希望得到他们指导的调查人员接触的医疗设备专家。提供成像设备 通过TBICSR跨越了磁共振成像(MRI)、正电子发射断层扫描(PET)、 计算机断层扫描(CT)、超声(US)和光学成像。最后，TBICSR得到以下工作人员的支持 在进行研究成像研究和动物处理方面有超过60年的经验 管理层。在上一个CCSG周期中，TBICSR获得了“杰出”排名。资源的优势 过去和现在都是其成像模式领导者和各种专业专业的专业知识 可提供仪器以满足癌症联盟成员的成像需求。活体成像是一种 无创性和纵向研究疾病过程和治疗反应的宝贵方法 动物，这是如此重要的财团研究，在人类研究之前。

PROJECT SUMMARY: TRANSLATIONAL BIOIMAGING CORE SHARED RESOURCE (TBICSR) In vivo imaging biomarkers have become indispensable in cancer research. The Translational BioImaging Core Shared Resource (TBICSR) provides a variety of imaging resources and support for Fred Hutch/University of Washington Cancer Consortium research through the interdisciplinary operations of shared resources across institutions. The goals of TBICSR are to make the widest range of high-end imaging resources available to Consortium members in a cost effective and efficient manner. TBICSR accopmplishes this by implementing a shared use model of imaging resources (and expertise). This is the most cost-effective way to make a wide range of imaging resources available to Consortium members regardless of usage volume at an individual site. Efficiency in enacting studies is enabled by allowing skilled users to access equipment via on-line scheduling and also by providing consultation services for prospective investigators seeking advice regarding imaging options. When consultation is requested, an imaging specialist is available to assist in Institutional Animal Care and Use Committee (IACUC) writing, arrangement of inter-institutional transportation and housing if needed, and system scheduling. Optimization of imaging resources is further supported through faculty imaging modality experts that engage with investigators that desire their guidance. Imaging equipment available through TBICSR spans the range of magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), ultrasound (US), and optical imaging. Finally, TBICSR is supported by staff with greater than 60 years of experience in conducting research imaging studies and in animal handling and management. TBICSR obtained “Outstanding” ranking in the last CCSG cycle. The strengths of the resource were and continue to be the expertise of its imaging modality leaders and the large variety of specialized major instrumentation available to serve the imaging needs of Cancer Consortium members. In vivo imaging is an invaluable way to non-invasively and longitudinally study the disease process and therapeutic response in animals, which is so vital to Consortium research, prior to human studies.