IMAGINE

IMAGINE项目将开发下一代跨尺度成像技术，以实现对生物系统结构和功能的综合研究。它将重点发展和整合四大颠覆性显微镜技术，即：x射线成像、冷冻电子显微镜、冷冻与动态超分辨率显微镜和大体积活体光学显微镜。它将进一步开发人工智能驱动的图像分析和数据集成/共享能力，这些能力需要将这些技术联系起来，并使其数据广泛可用。为了利用它们的力量来应对一些最紧迫的社会挑战，IMAGINE将准备将其新的成像技术部署在野外，在欧洲的海洋和海岸线上，以便在自然环境中收集环境标本，并通过最高分辨率的成像技术进行研究。IMAGINE技术目前处于物理和工程的前沿，因此只能单独供专家使用。该项目旨在通过开发和验证它们的服务就绪性，将它们带到欧洲生命科学用户社区，以便它们可以作为欧洲研究基础设施（RIs）的未来服务提供。为此目的，该计划将训练国际扶轮职员如何操作及使用IMAGINE技术。为了促进商业仪器的广泛传播，IMAGINE将与成像领域的主要仪器制造商共同开发学术界和工业界的技术，促进开放式创新。生命科学界越来越依赖RIs来获取越来越复杂和快速发展的科学仪器。IMAGINE开发的跨尺度成像技术将对欧洲的突破性研究至关重要，这是解决我们社会未来将面临的一些最大挑战所迫切需要的。

The IMAGINE project will develop the next generation of scale-crossing imaging technologies to enable an integrated investigation of structure and function of biological systems. It will focus on developing and integrating four major disruptive microscopy technologies, namely: X-ray imaging, cryo electron microscopy, cryo and dynamic super-resolution microscopy and large volume intravital light microscopy. It will furthermore develop the AI-powered image analysis and data integration/sharing capabilities, that are needed to correlate these technologies and make their data widely available. To harness their power for some of the most pressing societal challenges, IMAGINE will prepare its new imaging technologies to be deployed in the field, on Europe’s seas and coastlines, so that the collection of environmental specimen in their natural context can be coupled with their study by highest resolution imaging technologies. The IMAGINE technologies are currently at the cutting edge of physics and engineering and therefore only available in isolation and to specialists. The project aims to bring them to the European life science user community at large by developing and validating them for service readiness, so that they can be provided as future services by Europe’s Research Infrastructures (RIs). To this end, the project will train RI staff on the operation and use of the IMAGINE technologies. To promote broad dissemination as commercial instruments, IMAGINE will develop technologies jointly between academia and industry promoting open innovation with key instrumentation manufacturers in the imaging field. The life science community increasingly relies on RIs to access ever more complex and rapidly developing scientific instruments. The scale-crossing imaging technologies developed by IMAGINE will be critical to empower groundbreaking research in Europe, that is so urgently needed to address some of the biggest challenges our societies will face in the future.