Association of Perceived Stress and Cognition

项目/摘要摘要 非洲裔美国人患阿尔茨海默氏症(AD)的可能性是白人的两倍，但很少有研究表明 重点研究了这些认知差异及其相关机制。少数群体感受到的压力，如 非裔美国人，直接影响认知，也在心血管疾病危险因素恶化和 不健康的行为，如吸烟、不适当的饮食和缺乏运动。进一步认识企业的作用 可改变的风险因素，如认知能力下降的感知压力，可能在发展中起重要作用。 有效的预防战略和解决老龄化人口中的健康差距。首要目标是 这项建议的目的是检查压力和认知之间的联系，心血管疾病危险因素的作用，以及相关的 健康差距。本研究提出的以患者为中心的研究生涯发展指导 该奖项包括涉及两项队列研究的数据分析，以及确定试点临床试验的可行性。 该计划描述了三个独立但相互关联的项目，旨在检查感知到的 压力和认知。 具体目标-1：这项研究将前瞻性地检查感知到的压力和事件之间的关系 非裔美国人和白人认知障碍的地域和种族原因 卒中(涉及)队列的差异(n=30,239)，并探索心血管危险因素是否在这种关系中起中介作用。 具体目标2：这项研究将评估感知压力与特定认知领域的关系 在非裔美国人和白人中有轻度认知障碍的血管贡献者中 Emory的前驱阿尔茨海默病(血管)队列研究(n=341)。 具体目标3：这项研究将确定一种新的基于网络的多学科减压的可行性 计划和评估该计划对感知压力、相关生物标记物和认知的影响 轻度认知障碍的非裔美国人和白人(n=30)。 候选人：候选人(Kulshreshtha医生)是家庭部董事会认证的家庭医生 和埃默里大学的预防医学。他的长期职业目标是成为一名独立的临床医生 研究人员调查行为和生活方式干预改善认知健康的机制 并缩小健康差距。本提案中描述的综合研究和培训计划将 以应聘者在心血管流行病学、健康差距和初级保健方面的先前经验为基础 临床工作。它将纳入新的认知和压力测量培训，以及临床试验，以 发展压力和认知研究领域的专门知识，以预防阿尔茨海默病。总体而言，本研究将形成 研究AD预防和干预的潜在机制和干预措施的大型研究的基础 让Kulshreshtha博士成为以患者为导向的临床研究的年轻研究员。

Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and related mechanisms. Perceived stress in minority groups such as African Americans, directly affects cognition and also plays a role in worsening of CVD risk factors and unhealthy behaviors such as smoking, improper diet, and physical inactivity. Further understanding the role of modifiable risk factors such as perceived stress in cognitive decline could have an important role in developing effective preventive strategies and addressing health disparities in aging populations. The overarching goal of this proposal is to examine the association of stress and cognition, role of CVD risk factors, and related health disparities. The research proposed in this Mentored Patient-Oriented Research Career Development Award includes data analyses involving two cohort studies and determining the feasibility of a pilot clinical trial. The plan describes three separate but interrelated projects designed to examine the association of perceived stress and cognition. Specific Aim-1: The study will prospectively examine the relationship between perceived stress and incident cognitive impairment among African Americans and Whites in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort (n=30,239) and explore if CVD risk factors mediate this relationship. Specific Aim-2: The study will assess the relationship of perceived stress with specific cognitive domains among African Americans and Whites with Mild Cognitive Impairment in the Vascular Contributors to Prodromal Alzheimer's disease (VASCULAR) cohort study (n=341) at Emory. Specific Aim-3: The study will determine the feasibility of a novel web-based multidisciplinary stress reduction program and assess the program's effects on perceived stress, related biomarkers, and cognition among African Americans and Whites with Mild Cognitive Impairment (n=30). Candidate: The candidate (Dr. Kulshreshtha) is a board certified Family Physician in the Department of Family and Preventive Medicine at Emory University. His long-term career goal is to become an independent clinician researcher investigating the mechanisms of behavioral and lifestyle interventions to improve cognitive health and reduce health disparities. The integrated research and training program described in this proposal will build on the candidate's prior experience in cardiovascular epidemiology, health disparities, and primary care clinical work. It will incorporate new training in cognitive and stress measurements, and clinical trials, to develop expertise in the area of stress and cognition research for AD prevention. Overall this research will form the basis for larger studies investigating potential mechanisms and interventions for AD prevention and establish Dr. Kulshreshtha as a young investigator in patient-oriented clinical research.