Administrative Supplement to Regulators of retinal metabolism in healthy and degenerating retinas

摘要： 视网膜具有高代谢活性，视网膜变性与 线粒体功能障碍、代谢失调和毒性氧化损伤。然而，在这方面， 关于代谢在正常条件下是如何维持的或如何失调的，我们知之甚少。 退化的视网膜。AMPK（AMP活化蛋白激酶）是代谢的关键调节因子 在高度代谢的组织中，并且是调节光感受器中代谢的候选者， 在视网膜代谢中的作用将在这个拟议的项目中进行严格的研究， 功能和功能丧失方法。过氧化物酶增殖活化受体γ 辅激活因子-α（PGC-1α）和β（PGC-1β）是藻类生物发生的关键调节因子。 腺苷一磷酸依赖性激酶（AMPK）是PGC-1的重要调节因子 活动本研究的目的是确定AMPK和PGC-1活性在视网膜病变中的作用， 光感受器

Abstract: The retina hashigh metabolic activity,and retinal degenerations have been associated with mitochondrial dysfunction, dysregulation of metabolism, and toxic oxidative damage. However, little is known about how metabolism is maintained under normal conditions or is dysregulated in degenerating retinas. AMPK (AMP-activated protein kinase)is a key regulator of metabolism in highly metabolic tissues and is a candidate to regulate metabolism in photoreceptors, and its role in retinal metabolism will be rigorously studied in this proposed project using both gain-of- function and loss-of-function approaches. Peroxisome proliferator-activated receptor gamma coactivator-alpha (PGC-1α) and beta (PGC-1β) are key regulators of mitochondrialbiogenesis. Adenosine monophosphate dependent kinase (AMPK) is an important regulator of PGC-1 activity. Our goal in this study isto determine the rolesof AMPK and PGC-1activity in retinal photoreceptors.