Pediatric Cardiovascular and Pulmonary Research Training Program

项目摘要/摘要 这是一个非常成功的项目的续签申请，该项目旨在吸引和培训博士生和 儿童心肺疾病基础研究的博士后研究 生物学。需要一个心血管和肺的细胞和分子基础的培训计划 疾病，尤其是对儿童疾病感兴趣的内科科学家，是基于明确的证据 在教职员工和实习生层面上，全国此类人员的数量都在下降。目前，很少有儿科医生 美国医疗中心的心脏病学或肺科奖学金计划提供了足够的培训 研究领域，无论是在法官席上，还是在结构化的临床调查中。我们的计划旨在解决 这需要从两个重要的角度：1)允许儿科和其他临床研究员对 基础研究，培养研究能力和职业培训；2)吸引和培养基础人才 博士后和博士后水平的科学家研究与心肺疾病有关的机制 童年。我们的计划是由前一个计划的评论者的反馈、来自以下方面的建议形成的 我们的教员和项目顾问，由过去的实习生，以及包括新的教员和核心项目 使我们能够扩展受训人员的培训经验。除了继续 我们在发育/细胞生物学和疾病的分子基础方面的强大培训，拟议的计划将 利用遗传学、干细胞生物学、基因组学和生物信息学方面的机构优势-所有这些 它们是现代研究基础的组成部分。此外，我们还有一个新合并的焦点 关于心肺系统感染，这是全世界儿科发病率和死亡率的主要原因。我们 我为4名博士后和2名博士后研究员维持了培训课程，不间断地2-3 一年的全职调查。教学研讨会的多学科核心加强了这一重点， 日记俱乐部和正式的课程作业是通过与 导师/项目管理员提供心肺关键方面的个性化教育 发展和疾病。我们的目标是：1)为学员提供广泛的职业指导 制定和制定以儿科疾病为重点的独立研究计划；2)促进 基础细胞和分子生物学、基因组学和生物信息学方面的培训以及临床翻译 研究；以及3)指导学员的发展，以便在完成培训后，成功 可能会出现对独立资金的竞争。

PROJECT SUMMARY/ABSTRACT This is a renewal application for a high successful program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular and molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a declining national pool of such individuals at both the faculty and trainee levels. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists at the pre- and post-doctoral levels to study mechanisms related to cardiorespiratory disease in childhood. Our program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the inclusion of new faculty and core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, the proposed program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics—all of which are components of the foundation of modern research. In addition, we have a newly incorporated focus on infection of the cardiorespiratory system, a leading cause of pediatric morbidity and mortality worldwide. We have maintained a training curriculum for 4 postdoctoral and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This focus is enhanced by a multidisciplinary core of didactic seminars, journal clubs and formal coursework that are designed for each trainee through consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; and 3) to guide our trainees’ development so that, after the completion of training, successful competition for independent funding is likely.