2022 Cornea and Ocular Surface Biology, Pathology and Regeneration GRC/GRS

项目摘要 眼表由角膜、结膜、眼睑和相关的腺体组成， 分泌泪膜。任何这些结构的发育不良或体内平衡的破坏都可能导致 角膜和眼表疾病，可导致视力丧失或失明。了解 眼表组织的发生及其在疾病或创伤后的正常功能和修复，对于 确定疾病相关基因和新药，可能导致创新疗法， 保持视觉健康。我们请求对戈登研究会议和研讨会的支持， 角膜和眼表面生物学，病理学和再生（GRC-COSBPR），2022年2月13日至18日，在 加州的文图拉海滩万豪酒店。2022年GRC-COSBPR的目标是汇集国际 该领域的领导者，并为最新的，最前沿的基础，转化和临床研究提供论坛 专注于加快将研究结果从实验室转化为临床研究。在过去的良好记录的基础上， 在过去的六次会议上，我们计划了9次关于眼表生物学关键范式转变创新的科学会议， 病理学和组织修复。会议的标题是：1。数据采集和分析的新方法; 2。 细胞相互作用，细胞外基质和形态发生; 3。基因组学与基因调控; 4. 角膜及眼表创伤修复的研究进展; 5.眼表疾病的发病机制和 疾病; 6.眼表干细胞; 7.眼表的炎症和再生; 8. 角膜和眼表的疾病和健康; 9.眼表研究的小说翻译 治疗我们正在组织一个多样化的，性别平衡的会议，邀请来自北方和拉丁美洲的发言者。 美国、英国、以色列、亚洲（日本、印度、中国）和澳大利亚。将特别强调 通过邀请妇女和代表性不足的少数民族来增加多样性。每场会议将由一名 早期职业科学家和资深研究员的搭档会议将包括延长时间， 讨论。每次会议的一部分是不承诺从提交的摘要中选择发言者，特别是 早期职业调查员GRC会议将包括一个“电源小时”，讨论挑战妇女和 代表性不足的少数群体在科学以及多样性和包容性问题上面临的挑战。2022年的GRC将是 在此之前，第五届为期两天的戈登研究研讨会（GRS）由专门的学生和博士后领导。的 GRS为年轻的科学家提供了一个机会，让他们在一个不令人生畏的环境中展示自己的研究， 一些资深科学家的支持和反馈。会议的GRS开始促进社区建设 和长期的关系。2022年GRC-COSBPR会议将由GRC和该计划进行宣传 更新将通过网站和Twitter和Facebook等社交媒体发布，以提高知名度 在年轻科学家和实习生中。我们相信我们的计划与NEI的科学目标及其 支持将使我们能够提供一次高质量和成功的会议。

Project Summary The ocular surface is comprised of the cornea, conjunctiva, eyelids and associated glands that are responsible for secretion of the tear film. Dysgenesis or disruption of the homeostasis of any of these structures can lead to corneal and ocular surface diseases, which can result in loss of eyesight or cause blindness. Understanding the genesis of the ocular surface tissues, and its normal function and repair after disease or trauma, is crucial for identifying disease-associated genes and novel drugs that may lead to innovative therapies that are essential for maintaining visual health. We request support for the Gordon Research Conference and Seminar of the Cornea and Ocular Surface Biology, Pathology and Regeneration (GRC-COSBPR), February 13-18, 2022, at Ventura Beach Marriott in California. The goal of the 2022 GRC-COSBPR is to bring together international leaders in the field and provide a forum for the most recent, cutting-edge basic, translational and clinical research focused on expediting translation of findings from bench to bedside. Building on the strong track record from the past six meetings, we plan 9 scientific sessions on key paradigm shifting innovations in ocular surface biology, pathology, and tissue repair. The session titles are: 1. Novel Approaches to Data Acquisition and Analysis; 2. Cellular Interactions, the Extracellular Matrix, and Morphogenesis; 3. Genomics and Gene Regulation; 4. Advances in Cornea and Ocular Surface Wound Repair; 5. Mechanisms of Ocular Surface Disease and Disorders; 6. Stem cells of the Ocular Surface; 7. Inflammation and Regeneration of the Ocular Surface; 8. Sickness and Health of the Cornea and Ocular Surface; 9. Translation of Ocular Surface Research into Novel Therapies. We are organizing a diverse, gender-balanced meeting with speakers invited from North and Latin America, United Kingdom, Israel, Asia (Japan, India, China), and Australia. Special emphasis will be given to increase diversity by inviting women and underrepresented minorities. Each session will be co-moderated by an early career scientist paired with an established researcher. The sessions will include extended time for discussions. A portion of each session is uncommitted to select speakers from submitted abstracts, particularly early career investigators. The GRC conference will include a “Power Hour” to discuss challenges women and underrepresented minorities face in science and issues of diversity and inclusion. The 2022 GRC will be preceded by the 5th two-day Gordon Research Seminar (GRS) led by dedicated students and post-docs. The GRS provides an opportunity for young scientists to present their research in a non-intimidating environment, with support and feedback from a few senior scientists. The GRS start of the meeting fosters community building and long term relationships. The 2022 GRC-COSBPR meeting will be advertised by the GRC and the program updates will be posted on the website and via social media such as Twitter and Facebook to increase visibility among junior scientists and trainees. We believe our program is aligned with the scientific goals of NEI and its support will enable us to provide a high quality and successful meeting.