Mali ICEMR- Data Management and Biostatistics Core

核心B -总结 在过去十年中，疟疾控制工具的广泛使用极大地促进了 减少撒哈拉以南非洲与该病有关的发病率和死亡人数。然而，该区域继续 在全球疟疾死亡负担中，疟疾患者所占比例过高。此外，发病率 在某些情况下保持高水平但稳定，而在另一些情况下， 密集部署疟疾控制工具。本ICEMR的总体目标是了解变量 通过以下方式评估西非不同生态环境中当前疟疾控制干预措施的有效性 研究了解寄生虫之间的相互作用（对药物治疗的反应，基因型，配子体 生存），人类（免疫反应和宿主遗传学）和载体（生态学，行为和对 杀虫剂）和调节当地环境和人类行为的影响。数据的目标 管理和生物统计学（DMB）的核心是提供数据管理和生物统计支持， 马里的ICEMR调查员，以产生可靠和高质量的研究数据和数据分析。的 DMB的具体目标是：1]建立符合所有标准的数据管理系统办公室， 保密性、报告、数据质量和数据安全性，以支持与ICEMR合作 研究者，2]支持ICEMR研究者进行研究规划、研究实施和数据管理 活动包括：项目管理、数据收集、数据录入、研究质量保证、数据存储，以及 检索和更新标准作业程序，以及数据库管理和程序; 3] 支持ICEMR研究者进行方案设计和开发、研究监测以及两者的结合 中期和最终数据分析; 4]提供临床研究和数据分析方面的必要培训， 调查人员和技术人员符合所有标准。核心B将设在巴马科国立卫生研究院大学 马里卓越研究中心。

CORE B – SUMMARY Wide deployment of malaria control tools in the past decade has significantly contributed to substantial reduction of the incidence and deaths related to the disease in Sub-Sahara Africa. Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The Overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa through research to understand interactions between the parasite (response to drug treatment, genotypes, gametocyte survival), human (immune response and host genetics) and the vector (ecology, behaviors, and response to insecticides) and regulating influences of the local environment and human behavior. The goal of the Data Management and Biostatistics (DMB) Core is to provide data management and biostatistical support to the ICEMR investigators of Mali in order to produce reliable and high quality research data and data analysis. The specific aims of DMB are: 1]To set up a data management system office meeting all standards of confidentiality, reporting, data quality, and data security to support, in collaboration with the ICEMR investigators, 2] To support ICEMR investigators in study planning, study conduct and data management activities including: project management, data collection, data entry, study quality assurance, data storage, and retrieval, and updating standard operating procedures, and in database management and processes; 3] Support ICEMR investigators in protocol designing and development, in monitoring of studies, and in both interim and final data analyses; 4] To provide required training in clinical research and data analysis for investigators and technicians to meet all standards. The Core B will be based at the NIH-University of Bamako Center of Excellence in Research, Mali.