"Investigating the rebound effects of seasonal malaria chemoprevention (SMC) in Mali"
“调查马里季节性疟疾化学预防 (SMC) 的反弹效应”
基本信息
- 批准号:10697358
- 负责人:
- 金额:$ 13.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-05 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:4 year old5 year old8 year old9 year oldAdoptedAfrica South of the SaharaAgeAmodiaquineAnemiaAntibody ResponseAntigensAntimalarialsAreaArtemisininsBindingBiologicalBloodChemopreventionChildClassificationCohort StudiesCombined Modality TherapyCommunitiesControl GroupsCountryCulicidaeDataDevelopmentDiseaseDoseEffectivenessEligibility DeterminationEnrollmentExposure toFeverGenetic TranscriptionGenomicsHealthHospitalizationHumanImmune responseImmunityImmunologic MarkersImpairmentIncidenceInfectionInsecticidesInterventionLongitudinal cohort studyMalariaMaliMeasuresMerozoite Surface Protein 1MonitorMorbidity - disease rateNested Case-Control StudyOutcomeParasitesPhasePlasmodium falciparumPolymerase Chain ReactionPopulationPrevalencePrevention programPrevention strategyProspective, cohort studyPyrimethamineRecommendationRegimenReportingResearchRiskSeasonsSeveritiesStructureSulfadoxineSurveysTherapeuticTreatment ProtocolsWithdrawalWorkWorld Health Organizationage groupagedasexualcohortcompliance behaviorimprovedlow and middle-income countriesmalaria infectionmalaria transmissionmortalitynon-compliancepreventprogramsprophylacticscale uptransmission processtrend
项目摘要
Summary
Seasonal Malaria Chemoprevention (SMC) has been recommended by WHO for malaria endemic countries in
sub-Saharan Africa with strong seasonal malaria transmission since 2012. The intervention consists of the
administration of full treatment doses of Sulfadoxine-Pyrimethamine (SP) plus Amodiaquine to children less than
5 years of age every 4 weeks during the malaria transmission season for 3 to 4 rounds per year. Since 2016,
Mali has implemented the strategy countrywide. While significant decreases in malaria cases among the target
age group was observed, increasing trends in malaria among children 5 years and above is also reported in the
many settings where SMC is being implemented. The proposed study considers previous studies and pilot data
showing that approximately out of every eight children (12.5%) have historically received either no doses or a
single dose out of a the required four doses for the treatment regimen. This study seeks to enroll a large cohort
of children to permit a large-scale comparison between children previously compliant to SMC with a valid control
group (children not previously compliant to SMC) to elucidate the effects of phasing out of the SMC program due
to age ineligibility. The primary objective of this R01 proposal is to investigate the withdrawal effects of SMC
due to age eligibility requirements through the following three specific aims: 1) Determine malaria rebound
occurrence following SMC enrollment including its association with severe malaria and anemia; 2) Assess
changes in the age-specific P. falciparum prevalence, sexual and asexual parasites, and multiplicity of infection
following SMC deployment; and 3) Assess the change in immune response to malaria antigens during and
following SMC eligibility and the relationship with disease. The study will provide valuable information on the
impact of SMC stoppage at five years of age which can significant contribute improving monitoring malaria
outcomes in other low- and middle-income countries overall.
总结
世卫组织建议在疟疾流行国家采用季节性疟疾化学预防措施,
自2012年以来,撒哈拉以南非洲季节性疟疾传播强劲。干预措施包括
对小于15岁的儿童给予全治疗剂量的磺胺嘧啶-乙胺嘧啶(SP)加阿莫地喹,
在疟疾传播季节,每4周对5岁的儿童进行一次,每年进行3至4轮。2016年以来,
马里在全国范围内实施了该战略。虽然目标中的疟疾病例大幅减少,
2005年报告显示,5岁及以上儿童疟疾发病率呈上升趋势,
许多正在实施SMC的设置。拟议的研究考虑了以前的研究和试点数据
显示大约每八名儿童(12.5%)中有一名历史上没有接受过任何剂量或
治疗方案所需的四个剂量中的一个剂量。本研究旨在招募一个大型队列
允许对以前符合SMC的儿童与有效对照儿童进行大规模比较
小组(儿童以前不符合SMC),以阐明逐步淘汰SMC计划的影响,
年龄不合格。本R 01提案的主要目的是研究SMC的停药效应
由于年龄资格要求,通过以下三个具体目标:1)确定疟疾反弹
SMC入组后的发生率,包括其与重度疟疾和贫血的相关性; 2)评估
年龄特异性恶性疟原虫患病率、性寄生虫和无性寄生虫以及感染复数的变化
在SMC部署之后;和3)评估在SMC部署期间和之后对疟疾抗原的免疫应答的变化。
SMC合格性以及与疾病的关系。这项研究将提供有关
在5岁时停止SMC的影响,这可以大大有助于改善疟疾监测
其他低收入和中等收入国家的总体成果。
项目成果
期刊论文数量(0)
专著数量(0)
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Mahamoudou Toure其他文献
Mahamoudou Toure的其他文献
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{{ truncateString('Mahamoudou Toure', 18)}}的其他基金
"Investigating the rebound effects of seasonal malaria chemoprevention (SMC) in Mali"
“调查马里季节性疟疾化学预防 (SMC) 的反弹效果”
- 批准号:
10451972 - 财政年份:2022
- 资助金额:
$ 13.09万 - 项目类别:
Mali ICEMR- Data Management and Biostatistics Core
马里 ICEMR-数据管理和生物统计核心
- 批准号:
10381465 - 财政年份:2017
- 资助金额:
$ 13.09万 - 项目类别:
Mali ICEMR- Data Management and Biostatistics Core
马里 ICEMR-数据管理和生物统计核心
- 批准号:
10590592 - 财政年份:2017
- 资助金额:
$ 13.09万 - 项目类别:
Mali ICEMR- Data Management and Biostatistics Core
马里 ICEMR-数据管理和生物统计核心
- 批准号:
9891949 - 财政年份:
- 资助金额:
$ 13.09万 - 项目类别:
Mali ICEMR- Data Management and Biostatistics Core
马里 ICEMR-数据管理和生物统计核心
- 批准号:
9263340 - 财政年份:
- 资助金额:
$ 13.09万 - 项目类别:
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