课题基金 / 基金详情

Antimicrobial Resistance and Therapeutic Discovery Training Program

Antimicrobial Resistance and Therapeutic Discovery Training Program
抗菌素耐药性和治疗发现培训计划
批准号:
10381447
负责人:
Graeme L Conn
金额:
$26.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
未结题
起止时间:
2014-06-01 至 2025-05-31

项目摘要

项目成果

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中文摘要
翻译
抗药性微生物的挑战要求对新一代基础科学家进行广泛培训 并在抗感染研究的三个同等重要的子学科中接受教育:i.)机制: 抗菌素耐药性(AMR);抗菌素的发现和开发;以及3.)预防或预防的疫苗接种 治疗因AMR而缺乏抗菌治疗或无效的感染。接下来的 埃默里的抗菌素耐药性和治疗发现培训计划(ARTDTP)的成功 大学将帮助确保未来将有一支调查队伍可用来打击全球 AMR的健康问题。这种对未来科学家进行抗感染研究的需要是一个国际优先考虑的问题 进入临床实践的新型有效抗菌药(抗生素和抗病毒药物)的数量减少 在过去的二十年里,由于AMR,医生在治疗某些感染时经常面临的困难 或者是缺乏有效的治疗方法。因此,ARTDTP竞争性更新的目标是提供更高的 对精选的一批积极进取的研究生进行高质量的培训,使他们成为独立调查人员。 为此,ARTDTP将每年从四个研究生项目中挑选五名博士候选人 生物和生物医学科学研究生部和化学系,为期两年 在AMR和通过化学或免疫学进行治疗发现方面的培训 战略。ARTDTP的教职员工将作为受训者的指导者,他们高度 合作和跨越大学,在基础科学和临床部门的学术任命 医学院和埃默里艺术与科学学院。教育培训将包括 强调AMR研究和教育的子学科的学习过程和方案活动 以及药物发现或疫苗开发。ARTDTP将由一个执行委员会和 由外部咨询委员会每两年评估一次,并由学员在完成两年培训后进行评估 培训计划。从地方和全国招收代表不足的少数族裔学生 学院和大学将是ARTDTP的优先事项,并结合以大学为基础的具体倡议 将采用各种计划来最大限度地培训城市管理人员。除了在反恐怖主义的子学科中进行培训外 感染性研究ARTDTP受训者将接受严谨、可重复性等基本概念的教育 以及在生物和生物医学领域的职业生涯所需的道德规范。完成培训后 并获得博士学位,ARTDTP实习生将准备在以下领域担任博士后职位 学术界、政府或行业继续通过培训经验发展自己的兴趣 由我们的T32博士前项目提供。
英文摘要
The challenge of drug-resistant microbes requires that a new generation of basic scientists be broadly trained and educated in a triad of equally important sub-disciplines of anti-infective research: i.) mechanisms of antimicrobial resistance (AMR); ii.) antimicrobial discovery and development; and iii.) vaccinology to prevent or treat infections for which antimicrobial therapies are absent or becoming ineffectual due to AMR. The continued success of the Antimicrobial Resistance and Therapeutic Discovery Training Program (ARTDTP) of Emory University will help to ensure that a cadre of investigators will be available in the future to combat the global health problem of AMR. This need for future scientists in anti-infective research is an international priority given the reduced number of new, effective antimicrobials (antibiotics and antivirals) that have entered clinical practice in the past two decades and the difficulty often faced by physicians in treating certain infections because of AMR or the lack of effective therapeutics. Thus, the objective of the competitive renewal of ARTDTP is to provide high quality training to a select group of highly motivated graduate students for careers as independent investigators. Towards that end, ARTDTP will select five Ph.D. candidates yearly from four graduate programs within the Graduate Division of Biological and Biomedical Sciences and the Department of Chemistry for a two-year period of training in the areas of AMR and therapeutic discovery through chemical or immunologic-based strategies. ARTDTP faculty members who will serve as the pool of preceptors for trainees are highly collaborative and span the university with academic appointments in basic science and clinical departments of the School of Medicine and Emory College of Arts and Sciences. Educational training will consist of a course of study and programmatic events in sub-disciplines that emphasize research and education in AMR and drug discovery or vaccine development. ARTDTP will be governed by an Executive Committee and evaluated bi-yearly by an external Advisory Committee and by trainees after completion of their two-year program of training. Recruitment of under-represented minority students (URMS) from local and national colleges and universities will be a priority for ARTDTP and specific initiatives coupled with university-based programs will be employed to maximally train URMS. In addition to training in the sub-disciplines of anti- infective research ARTDTP trainees will receive education in the essential concepts of rigor, reproducibility and ethics that are needed for careers in the biological and biomedical fields. Upon completion of training and receipt of the Ph.D. degree, ARTDTP trainees will be ready to assume post-doctoral positions in academia, government or industry that continue their interests developed through the training experience provided by our T32 pre-doctoral program.
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RNA modification and antibiotic resistance
  • 批准号:
    10818852
  • 项目类别:
  • 资助金额:
    $9.92万
  • 财政年份:
    2020
  • 负责人:
    Graeme L Conn
  • 依托单位:
dsRNA regulation of the cytosolic innate immune system
  • 批准号:
    10736791
  • 项目类别:
  • 资助金额:
    $46.0万
  • 财政年份:
    2019
  • 负责人:
    Graeme L Conn
  • 依托单位:
dsRNA regulation of the cytosolic innate immune system
  • 批准号:
    9891948
  • 项目类别:
  • 资助金额:
    $39.0万
  • 财政年份:
    2019
  • 负责人:
    Graeme L Conn
  • 依托单位:
dsRNA regulation of the cytosolic innate immune system
  • 批准号:
    10359208
  • 项目类别:
  • 资助金额:
    $39.0万
  • 财政年份:
    2019
  • 负责人:
    Graeme L Conn
  • 依托单位:
海外基金