Qualification and Harmonization of PET/MRI for Cancer Clinical Trials

项目摘要 PET/MRI的主要局限性之一是缺乏准确的衰减校正手段， 导致对放射性示踪剂摄取的不准确和不一致的量化。PET的不一致性 量化防止在临床试验中广泛采用PET/MRI，在临床试验中，精确和 放射性示踪剂摄取的可重复性测量是必需的。我们在此应用程序中建议开发一种 评价基于MR的衰减校正技术和相关PET的标准方法学 为了使PET/MRI扫描仪有资格用于临床试验和临床工作，必须确保定量的准确性。这部作品 将在三个具体目标下进行。首先，我们将评估材料并为其创建物理模型 基于磁共振的衰减校正技术评价。我们随后将验证该幻影 使用患者研究来证明我们可以准确地估计测量到的活动的偏差 使用PET/MRI体模。最后，我们将对两者的重建参数进行协调 可用的PET/MRI扫描仪，并评估12个PET/ 核磁共振成像站点在两家PET/MRI制造商之间分配。最后，我们将结合PET/MRI 将协调数据纳入一项包括PET/MRI和PET/CT的全球协调研究。穿过 上述工作，我们的目标是创建一个标准化的方法来评估正电子发射计算机断层扫描的准确性 在正电子发射计算机断层扫描/磁共振成像环境中的量化。标准化的方法论将激励供应商开发 衰减校正方法，产生跨系统更一致的摄取估计，以及 使扫描仪合格的能力将有助于将PET/MRI应用于临床试验和临床护理。

Project Summary One of the central limitations of PET/MRI is the lack of accurate means of attenuation correction, which leads to inaccurate and inconsistent quantification of radiotracer uptake. The inconsistency of PET quantification prevents the widespread adoption of PET/MRI in clinical trials, where a precise and reproducible measurement of radiotracer uptake is required. We propose in this application to develop a standard methodology to evaluate MR based attenuation correction techniques and the related PET quantitation accuracy in order to qualify PET/MRI scanners for clinical trials and clinical work. This work will be done in three specific aims. First, we will evaluate materials and create a physical phantom for evaluation of MR based attenuation correction techniques. We will subsequently validate the phantom using a patient study to demonstrate that we can accurately estimate deviations of measured activity using the PET/MRI phantom. Finally, we will harmonize the reconstruction parameters on the two available PET/MRI scanners and evaluate the reproducibility of the quantitative accuracy across 12 PET/ MRI sites split between the two PET/MRI manufacturers. Finally we will incorporate the PET/MRI harmonization data into a global harmonization study that includes both PET/MRI and PET/CT. Through the work described, we aim to create a standardized approach to evaluate the accuracy of PET quantification in the setting of PET/MRI. A standardized methodology will incent vendors to develop attenuation correction methods that result in more consistent uptake estimates across systems, and the ability to qualify scanners will help the adoption of PET/MRI into clinical trials and clinical care.