Alcohol and Addiction Research Domain Criteria and Alcohol Use Disorder Recovery

项目摘要/摘要 酒精和成瘾研究领域标准(AARDoC)已被提议为以下方面提供一个框架 从心理和生物结构的角度理解酒精使用障碍(AUD)的本质 可以追溯到具有潜在生物学基础的特定行为功能(例如，神经功能障碍)。 AARDOC提出，澳元的发展、进步和维持是因为更高的激励 酒精突出，更多的负面情绪，和/或执行功能和冲动方面的障碍。 AARDOC于2015年提出，目的是改善澳大利亚大学在精准医学方面的努力。因此，它是 至关重要的是，应研究和验证基于AARDoC框架的临床评估 以便为AUD的临床决策和精准医学倡议提供信息。AARDOC还可以 在预测AUD治疗结果和AUD恢复方面有实用价值。有越来越多的证据 减少饮酒既是可以实现的，也与以下方面的功能改善有关 患有澳门氏症的个人。研究减少饮酒是否与有意义的恢复有关 功能是至关重要的，因为许多人不寻求治疗，因为他们不想 戒酒，然而治疗系统大多集中在戒酒作为必要和充分的 康复的条件。将康复的定义扩大到包括非禁欲的康复和其他 功能结果可以提高非戒断性治疗目标在提供者中的可接受性，增加 在那些不愿完全戒烟的澳大利亚人中寻求治疗，并最终减少 未经治疗的澳大利亚人的公共卫生负担。为了解决这些理解上的差距，这项研究将建立一个 关于可用于识别AARDOC的临床评估的经验性知识库 构建并将检查AARDoC结构是否与一种新的酒精类型相关联 在接受酒精治疗的个人中，以消费和功能为定义的康复。至 为了达到研究目标，对3600多名个体(N)进行了AARDoC结构的综合数据分析 =3,672)参与了三项由公共资金资助的酒精治疗研究的人将接受检查。这项研究 我将研究澳元恢复的广泛定义和澳元恢复后长达10年的预测 治疗插曲。这项研究的结果将直接应用于临床实践和未来的研究 关于澳元精准医学。 项目相关性 这项研究试图更好地了解酒精使用障碍患者的可变性 正在寻求治疗和从酒精使用障碍中恢复的预测因素。这一结果将为建立一个科学的 将帮助指导未来的精准医学计划、酒精治疗计划和 客户、临床医生、项目评估者和政策制定者之间的决策，这最终可能 改善临床结果，减少酒精使用障碍的公共健康负担。

Project Summary/Abstract The alcohol and addiction research domain criteria (AARDoC) has been proposed to provide a framework for understanding the nature of alcohol use disorder (AUD) in terms of psychological and biological constructs that can be traced to a specific behavioral function with an underlying biological basis (e.g., neural dysfunction). The AARDoC proposes that AUD develops, progresses, and is maintained because of heightened incentive salience for alcohol, greater negative emotionality, and/or impairments in executive functioning and impulsivity. AARDoC was proposed in 2015 with the goal of improving efforts at precision medicine for AUD. As such, it is critically important that clinical assessments based on the AARDoC framework be studied and validated in order to inform clinical decision making and precision medicine initiatives for AUD. The AARDoC may also have utility in predicting AUD treatment outcomes and AUD recovery. There is an accumulation of evidence that drinking reductions are both achievable and associated with improvements in functioning among individuals with AUD. Examining whether drinking reductions can be associated with meaningful recovery of functioning is critically important because many individuals do not seek treatment because they do not want to abstain from alcohol, yet treatment systems are mostly focused on abstinence as a necessary and sufficient condition for recovery. Expanding the definition of recovery to include non-abstinent recoveries and other functional outcomes could increase acceptability of non-abstinent treatment goals among providers, increase treatment seeking among those with AUD who are not willing to abstain completely, and ultimately reduce the public health burden of untreated AUD. To address these gaps in understanding, this study will build an empirical knowledge base regarding clinical assessments that could be used to identify the AARDoC constructs and will examine whether the AARDoC constructs are associated with a novel typology of alcohol recovery, defined by consumption and functioning, among individuals who receive alcohol treatment. To achieve the study aims, integrative data analysis of AARDoC constructs among more than 3600 individuals (n = 3,672) who participated in three publicly funded alcohol treatment studies will be examined. This research will examine a broad definition of recovery and prediction of AUD recovery up to 10 years following an AUD treatment episode. The results from this study will be directly applicable to clinical practice and future research on AUD precision medicine. Project Relevance This study seeks to gain a better understanding of variability among individuals with alcohol use disorder who are seeking treatment and predictors of recovery from alcohol use disorder. The results will build a scientific knowledge base that will help guide future precision medicine initiatives, alcohol treatment planning, and decision-making among clients, clinicians, program evaluators, and policy makers, which may ultimately improve clinical outcomes and decrease the public health burden of alcohol use disorder.