Cortical Underpinnings of Gait and Falls in Aging: A Novel Brain-Body Imaging Approach

项目总结 这位候选人是阿尔伯特大学神经病学和儿科系的研究助理教授 爱因斯坦医学院。拟议的K01指导研究科学家发展奖将促进 候选人作为独立翻译研究员在#年流动性下降研究中的发展 以皮质贡献为重点的衰老。提议的应用程序的总体目标是提供 具有运动学综合分析高级生物医学信号处理培训的候选人 和行走过程中的脑电神经生理记录，以提供临床暴露于老年人和 行动能力评估，以及帮助他实现长期职业生涯的纵向研究的设计 在流动性神经流行病学中确立作为翻译研究人员的独立性的目标 老龄化程度有所下降。职业发展计划以应聘者在认知神经科学方面的专业知识为基础 通过先前对年龄相关的行为和脑电生理评估进行培训而获得的老化 认知和运动功能的改变。提出了严格的培训计划，强调正规指导 在生物医学信号处理、跌倒风险评估、 流行病学、生物统计学、拨款撰写和研究伦理。高级生物医学信号培训 确定行走过程中的运动性脑电信号的处理将通过课程和一对一的 爱因斯坦认知神经生理学实验室提供的一个教程，生物医学工程学 纽约城市学院、MathWorksTM和斯沃茨计算中心的系 圣地亚哥的神经科学。将通过以下途径获得老年人的临床接触和行动能力评估 认知和运动衰老实验室的大脑老化和正在进行的移动性研究中心。培训 流行病学研究设计、生物统计学和研究伦理将通过临床研究获得 由爱因斯坦-蒙特菲奥里临床和翻译研究所提供的培训计划。一系列 补充充实活动将补充教学训练，并提高候选人的学术能力 领导才能。随之而来的指导研究项目提出了一个合并的横截面 和纵向调查，以确定中枢神经系统对年龄相关的贡献 移动业务的衰落。研究方案的重点是开发一种基于新型脑电的靶向应用 技术-移动脑体成像(MOBI)在主动行走中检查步态之间的联系， 随着年龄的增长，认知能力下降。候选人将从两个资助计划的联合资源中受益 爱因斯坦的项目：跌倒的生物和神经机制(PI：J.Verghese)和中枢控制 老龄化中的机动性(PI：R.Holtzer)。在机构层面，候选人可以接触到一系列不同的 CTSA赞助的核心资源，如生物统计学和研究设计。完成概述的活动 在此KO1应用程序中，将提供临床培训和有指导的研究经验，以准备 候选人将实现他的长期目标，即进行创新的翻译研究，以增强皮质- 以预防和干预为基础，改善老年人的行动能力和生活质量。

PROJECT SUMMARY The Candidate is a Research Assistant Professor in the Department of Neurology and Pediatrics at the Albert Einstein College of Medicine. The proposed K01 Mentored Research Scientist Development Award will foster the Candidate’s development as an independent translational researcher in the study of mobility decline in aging with a focus on cortical contributions. The overall goal of the proposed application is to provide the Candidate with training in advanced biomedical signal processing for integrated analysis of kinematic and EEG neurophysiological recordings during walking, to provide clinical exposure to geriatric and mobility assessment, and the design of longitudinal studies to help him achieve his long-term career goal of establishing independence as a translational researcher in the neuro-epidemiologyof mobility decline in aging. The Career Development Plan builds on the Candidate’s expertise in cognitive neuroscience of aging, obtained through prior training in behavioral and EEG electrophysiological assessment of age-related changes in cognitive and motor functions. A rigorous training plan is proposed, emphasizing formal instruction and hands-on clinical and research experience in biomedical signal processing, fall risk assessment, epidemiology, biostatistics, grant writing and research ethics. Training in advanced biomedical signal processing to determine kinematic-EEG signals during walking will be obtained through courses and one-on- one tutorials offered by the Cognitive Neurophysiology Laboratory at Einstein, the Biomedical Engineering Department at the City College of New York, MathWorksTM, and the Swartz Center for Computational Neuroscience in San Diego. Clinical exposure to geriatric and mobility assessment will be obtained through the Center for the Aging Brain and ongoing mobility investigations at the Cognitive & Motor Aging Lab. Training in epidemiological study design, biostatistics and research ethics will be obtained through the Clinical Research Training Program offered by the Einstein-Montefiore Institute for Clinical and Translational Research. A series of supplemental enrichment activities will complement didactic training and enhance the Candidate’s academic leadership skills. The accompanying mentored research project proposes a combined cross-sectional and longitudinal investigation to determine contributions of the central nervous system to age-related decline in moblitiy. The research proposal focuses on developing targeted applications of a novel EEG-based technique - Mobile Brain-BodyImaging (MOBI) during active walking to examine the link between gait, cognition and falls in aging. The Candidate will benefit from the combined resources on two funded Program Projects at Einstein: the Biological and Neural Mechanism of Fall (PI: J. Verghese) and the Central Control of Mobility In Aging (PI: R. Holtzer). At the institutional level, the Candidate has access to a diverse array of CTSA-sponsored Core resources such as Biostatistics and Study Design. Completion of the activities outlined in this KO1 application will provide clinical training and mentored research experiences that will prepare the Candidate to achieve his long-term goal of conducting innovative translational research to enhance cortical- based prevention and intervention to improve mobility and quality of life in older adults.