Cortical Underpinnings of Gait and Falls in Aging: A Novel Brain-Body Imaging Approach

 描述（由申请人提供）：候选人是阿尔伯特爱因斯坦医学院神经病学和儿科系的研究助理教授。拟议的K 01指导研究科学家发展奖将促进候选人作为一个独立的翻译研究人员在老龄化的流动性下降的研究，重点是皮质的贡献的发展。拟议申请的总体目标是为候选人提供高级生物医学信号处理方面的培训，以综合分析行走期间的运动学和EEG神经生理学记录，提供老年人临床暴露和移动性评估，和纵向研究的设计，以帮助他实现他的长期职业目标，建立独立的翻译研究员在神经，老龄化中行动能力下降的流行病学。职业发展计划建立在候选人在衰老认知神经科学方面的专业知识基础上，这些专业知识是通过对认知和运动功能中与年龄相关的变化进行行为和EEG电生理评估的先前培训获得的。提出了严格的培训计划，强调在生物医学信号处理，跌倒风险评估，流行病学，生物统计学，赠款写作和研究伦理方面的正式教学和实践临床和研究经验。通过爱因斯坦认知神经生理学实验室、纽约城市学院生物医学工程系、MathWorksTM和圣地亚哥斯沃茨计算神经科学中心提供的课程和一对一辅导，将获得高级生物医学信号处理方面的培训，以确定行走过程中的运动脑电图信号。将通过大脑老化中心和认知与运动老化实验室的持续移动性调查获得老年人的临床暴露和移动性评估。将通过Einstein-Montefiore临床和转化研究所提供的临床研究培训计划获得流行病学研究设计、生物统计学和研究伦理学方面的培训。一系列补充性的丰富活动将补充教学培训，提高候选人的学术领导能力。伴随的指导研究项目提出了一个结合横截面和纵向调查，以确定中枢神经系统的贡献，与年龄相关的流动性下降。该研究应用的重点是开发一种新的基于EEG的技术-移动的脑体成像（MOBI）在主动行走过程中的目标应用，以检查步态，认知和衰老中的福尔斯之间的联系。候选人将受益于爱因斯坦两个资助项目的综合资源：跌倒的生物和神经机制（PI：J. Verghese）和衰老中移动性的中央控制（PI：R. Holtzer）。在机构层面，候选人可以获得CTSA赞助的各种核心资源，如生物统计学和研究设计。完成本KO 1申请中概述的活动将提供临床培训和指导研究经验，使候选人能够实现其长期目标，即进行创新转化研究，以加强基于皮质的预防和干预，从而改善老年人的活动能力和生活质量。

 DESCRIPTION (provided by applicant): The Candidate is a Research Assistant Professor in the Department of Neurology and Pediatrics at the Albert Einstein College of Medicine. The proposed K01 Mentored Research Scientist Development Award will foster the Candidate's development as an independent translational researcher in the study of mobility decline in aging with a focus on cortical contributions. The overall goal of the proposed application is to provide the Candidate with training in advanced biomedical signal processing for integrated analysis of kinematic and EEG neurophysiological recordings during walking, to provide clinical exposure to geriatric and mobility assessment, and the design of longitudinal studies to help him achieve his long-term career goal of establishing independence as a translational researcher in the neuro-epidemiology of mobility decline in aging. The Career Development Plan builds on the Candidate's expertise in cognitive neuroscience of aging, obtained through prior training in behavioral and EEG electrophysiological assessment of age-related changes in cognitive and motor functions. A rigorous training plan is proposed, emphasizing formal instruction and hands-on clinical and research experience in biomedical signal processing, fall risk assessment, epidemiology, biostatistics, grant writing and research ethics. Training in advanced biomedical signal processing to determine kinematic-EEG signals during walking will be obtained through courses and one-on- one tutorials offered by the Cognitive Neurophysiology Laboratory at Einstein, the Biomedical Engineering Department at the City College of New York, MathWorksTM, and the Swartz Center for Computational Neuroscience in San Diego. Clinical exposure to geriatric and mobility assessment will be obtained through the Center for the Aging Brain and ongoing mobility investigations at the Cognitive & Motor Aging Lab. Training in epidemiological study design, biostatistics and research ethics will be obtained through the Clinical Research Training Program offered by the Einstein-Montefiore Institute for Clinical and Translational Research. A series of supplemental enrichment activities will complement didactic training and enhance the Candidate's academic leadership skills. The accompanying mentored research project proposes a combined cross-sectional and longitudinal investigation to determine contributions of the central nervous system to age-related decline in mobility. The research application focuses on developing targeted applications of a novel EEG-based technique - Mobile Brain-Body Imaging (MOBI) during active walking to examine the link between gait, cognition and falls in aging. The Candidate will benefit from the combined resources on two funded Program Projects at Einstein: the Biological and Neural Mechanism of Fall (PI: J. Verghese) and the Central Control of Mobility in Aging (PI: R. Holtzer). At the institutional level, the Candidate has access to a diverse array of CTSA-sponsored Core resources such as Biostatistics and Study Design. Completion of the activities outlined in this KO1 application will provide clinical training and mentored research experiences that will prepare the Candidate to achieve his long-term goal of conducting innovative translational research to enhance cortical- based prevention and intervention to improve mobility and quality of life in older adults.