2022 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Seminar

摘要 要求为研究生和博士后研究员以及初级和中期教职员工提供部分支持 参加戈登研究研讨会和会议(GRS/GRC)，题为“纤溶酶原激活” 和胞外蛋白分解“，将分别于2022年2月5-6日和6-11日在加利福尼亚州文图拉举行。 这将是第18届GRC，因为自1990年以来，该会议每两年连续举行一次。这个 2022年GRC的重点将放在细胞外蛋白水解酶的机制和治疗靶点上， 包括纤溶酶原、纤溶酶原激活剂、凝血酶、基质金属蛋白酶、 它们的前体、抑制物和效应物。最近的数据表明，循环中的蛋白酶表达 组织的血管外间隔与许多病理过程有关。我们被邀请的 演讲者和讨论领袖将介绍他们最新和正在出现的工作，涉及一系列基本的 科学和临床主题，包括心血管疾病、衰老、脑血管功能、代谢 疾病、肌肉骨骼和神经退行性疾病、癌症、感染和免疫、组织重塑 和再生，以及创伤。重点将放在强调这些蛋白质扮演的角色 疾病修饰物以及使用或靶向这些因素进行诊断和治疗的效用。其中之一 2022年GRC会议的主要目标是将基础研究转化为临床。出席者将是 通过邀请和从在线提交的申请中选择。他们将被选为代表不同的 研究的范围，重点是机会均等和所有人的包容 人口统计指标。将作出更多努力，招募任职人数不足的妇女和科学家。 小组作为GRS和GRC的会议领导人和发言者。事实上，这是一种预期的力量 会议将是该领域青年科学家与讨论负责人的互动和联网 还有扬声器。相关的GRS是会议的一个较年轻的特点，将提供一个独特的 学员和初学者有机会介绍他们的研究并分享GRC的经验。这 在Leading的支持下，研究生和博士后研究员将组织为期两天的研讨会 研究人员和GRC主席，并将允许纤溶酶原激活领域的初级研究人员 和细胞外蛋白分解一起讨论他们目前未发表的研究，同时建立 与同行的非正式网络可能会带来终生的合作和科学成就。

Summary Partial support is requested for graduate students and post-doctoral fellows, and junior and midcareer faculty to participate in the Gordon Research Seminar and Conference (GRS/GRC) entitled “Plasminogen Activation and Extracellular proteolysis”, which will be held in Ventura, CA on February 5-6 and 6-11, 2022, respectively. This will be the 18th GRC, as the conference has been held continuously every two years since 1990. The focus of the 2022 GRC will be on mechanisms and therapeutic targets of extracellular proteolytic enzymes, including plasmin(ogen), plasminogen activators, coagulation proteases, matrix-metalloproteinases (MMPs), their precursors, inhibitors, and effectors. Recent data suggest that the expression of proteases in circulation and the extravascular compartments of tissues is tied to numerous pathological processes. Our invited speakers and discussion leaders will present their recent and emerging work across a spectrum of basic science and clinical topics, including cardiovascular disease, aging, cerebrovascular function, metabolic diseases, musculoskeletal and neurodegenerative diseases, cancer, infection and immunity, tissue remodeling and regeneration, as well as trauma. Priority will be placed on highlighting both the role these proteins play as disease modifiers as well the utility of employing or targeting these factors for diagnosis and therapy. One of the major goals for the 2022 GRC meeting is translating basic research into the clinic. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of research, with a strong emphasis on equity of opportunity and inclusion of individuals across all demographic metrics. Additional efforts will be committed to recruit women and scientists of underrepresented groups as session leaders and speakers for both the GRS and GRC. Indeed, an intended strength of this meeting will be the interaction and networking of the young scientists in the field, with the discussion leaders and the speakers. The associated GRS, which is a younger feature of the conference, will provide a unique opportunity for trainees and beginning scientists to present their research and share the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chairs, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current unpublished research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.