CACHET - Environmental Biomarkers Core

1.环境生物标志物核心(EBC)：摘要 环境生物标志物核心(EBC)的总体目标是提供生物分析服务，以支持 芝加哥健康与环境中心(CACHET)成员在进行环境健康研究 芝加哥大学(UofC)和伊利诺伊大学芝加哥分校(UIC)。通过提供必要的 评估广泛的环境生物标志物的实验专业知识，EBC直接贡献 Cachet的使命是减轻我们社区内的环境健康不平等。为此， EBC由两个免费的子核组成：1)基于质谱学的环境暴露子核 核心是P30特定于成员可用的服务和资源，以及2)暴露的生物标记物 影响和敏感性分核心，利用UofC和UIC的现有机构资源，以及 简化对会员的服务。UIC的P30特定环境暴露分核心将使用MASS 用于评估有毒化学品、重金属和类金属、除草剂、农药、全氟烷基的光谱分析 生物和环境样品中的物质、类固醇和DNA氧化产物等。 将根据需要开发和验证环境化合物的新分析方法。 暴露影响和易感性的生物标记物次核心将利用既定的机构优势 在微生物组测序中，代谢组学、蛋白质组学、基因组学、表观基因组学和转录组学对两者都有影响 校园。此外，生物信息学支持由国际和平倡议发起的所有研究项目和设施核心 活动将由两个伙伴机构的既定机构核心提供。对于所有这些服务， 纪念章会员将享有环境健康研究项目的优先准入和补贴费率 由中心资源提供，并利用机构分担智力专业知识、管理 平台和在高端仪器设备上的大量投资。这些综合资源有助于解决EBC 提供有关暴露、疾病和治疗的生物标记物的定性和定量数据 人体受试者、模型系统和环境污染物的反应和水平 以补贴价格提供环境样品，并优先接触中心成员。

1. ENVIRONMENTAL BIOMARKERS CORE (EBC): ABSTRACT The overall goal of the Environmental Biomarkers Core (EBC) is to provide bioanalytical services in support of ChicAgo Center for Health and EnvironmenT (CACHET) members conducting environmental health research at the University of Chicago (UofC) and University of Illinois at Chicago (UIC). By providing the necessary experimental expertise to assess a wide range of environmental biomarkers, the EBC directly contributes to CACHET’s mission to mitigate environmental health inequities within our communities. Toward that end, the EBC consists of two complimentary Sub-Cores: 1) a mass spectrometry-based Environmental Exposures Sub- Core that is P30-specific in services and resources available to members, and 2) a Biomarkers of Exposure Effects and Susceptibility Sub-Core that leverages existing institutional resources at UofC and UIC and streamlines services to members. The P30-specific Environmental Exposures Sub-Core at UIC will use mass spectrometry to assess toxic chemicals, heavy metals and metalloids, herbicides, pesticides, perfluoroalkyl substances, steroids and DNA oxidation products, among others, in both biological and environmental samples. New assays for environmental compounds will be developed and validated as needed by CACHET investigators. The Biomarkers of Exposure Effects and Susceptibility Sub-Core will leverage established institutional strengths in microbiome sequencing, metabolomics, proteomics, genomics, epigenomics and transcriptomics on the two campuses. Further, bioinformatics support for all CACHET PI-initiated research projects and Facility Core activities will be provided from established institutional cores at both partner institutions. For all of these services, CACHET members will enjoy priority access and subsidized rates for environmental health research projects provided by Center resources and leveraging institutional cost-sharing of intellectual expertise, management platforms and heavy investments in high-end instrumentation. These combined resources help address the EBC mission to provide qualitative and quantitative data regarding biomarkers of exposure, disease and therapeutic responses as well as levels of environmental contaminants in human subjects, model systems and environmental samples at subsidized rates and with priority access to Center members.