Research Training in Infectious Diseases

描述(由申请人提供)：纪念斯隆-凯特琳癌症中心传染病培训计划的目标是为MD和MD/PhD研究员提供以下领域的博士后研究培训：1)传染病发病机制；2)宿主对感染的防御；3)对人类免疫防御的翻译研究；以及4)免疫受损宿主中传染病的临床研究。培训期限为两年，需要六个职位，三个为一年级研究员，三个为二年级研究员。所有六个职位都将由来MSKCC接受传染病专科培训的临床医生填补。这些研究员将进入研究-培训计划，并在完成临床培训后得到这笔培训补助金的支持，为期两年。我们培训计划的目标是培训基础和临床研究人员，从事宿主防御、微生物发病机制、传染病诊断和基于免疫的抗微生物治疗等领域的学术生涯。这一培训方案将提供一个有组织的环境，让传染病和相关教员密集参与研究员的培训。参与这项培训资助的教师将在一系列研究领域提供指导，从对感染病原体的先天/获得性免疫反应到异基因移植患者感染的临床研究。临床研究的核心课程由现有的K-30奖项资助，名为纪念斯隆·凯特琳癌症中心的临床研究方法论课程，并提供设计和完成临床研究的教学。已经为进行实验室研究的研究员制定了研讨会、期刊俱乐部、实验室会议和正式课程的课程。

DESCRIPTION (provided by applicant): The objective of the Training Program in Infectious Diseases at Memorial Sloan Kettering Cancer Center is to provide post-doctoral research training to MD and MD/PhD fellows in the following areas: 1) Infectious disease pathogenesis; 2) Host defense against infection; 3) Translational studies of human immune defenses against infection; and 4) Clinical investigation of infectious diseases in immunocompromised hosts. The duration of training will be two years and six positions are requested, three for first year fellows and three for second year fellows. All six positions will be filled by clinicians who come to MSKCC for training in the subspecialty of Infectious Diseases. These fellows will enter the research-training program and be supported by this training grant for two years after the completion of their clinical training. The objectives of our training program are to train basic and clinical investigators for academic careers in the areas of host defense, microbial pathogenesis, infectious diseases diagnosis and immune-based anti-microbial therapy. This training program will provide a structured environment with intensive involvement of the Infectious Diseases and associated faculty in the training of fellows. Faculty participating on this training grant will provide mentorship in a range of research areas spanning from innate/adaptive immune responses to infectious pathogens to clinical studies of infections in allogeneic transplant patients. A core curriculum in clinical investigation is funded by an existing K-30 award entitled Clinical Research Methodology Curriculum at Memorial Sloan Kettering Cancer Center and provides didactic teaching in the design and completion of clinical studies. A curriculum of seminars, journal clubs, lab meetings and formal courses has been developed for fellows performing laboratory-based research.