Electronic cigarette use during pregnancy and the impact on newborn metabolic profile and perinatal health outcomes

项目摘要 电子烟（e-cigarettes）自2004年首次进入世界市场以来， 被宣传为一种更健康的替代品和对现有烟草产品的戒烟帮助。 具有 青年 电子烟使用 近年来急剧增加，成为最常用的吸烟产品， 年轻人自2014年以来这是特别吸引孕妇吸烟者谁是动机 改变他们的吸烟习惯，改善他们和胎儿的健康。然而，潜在的不利因素 最近爆发的电子烟的影响，它是否会增加妇女及其 发育中的胎儿，未知。本研究的总体目标是：（1）确定 妇女从孕前到围产期的吸烟模式以及随着时间的推移，2）确定 怀孕期间使用电子烟与怀孕、围产期和婴儿相关不良反应之间的关联 结果，以及3）确定怀孕电子烟使用与代谢特征之间的关联 出生时测量。我们建议对2016年至2019年期间分娩的妇女进行监测研究， 2018年，参加了美国疾病控制和预防中心（CDC）发起的妊娠风险 评估监测系统调查。详细的吸烟信息，包括传统的 在孕前、妊娠晚期和分娩后使用香烟和电子烟， 收集。我们将进一步将田纳西州和爱荷华州妇女的PRAMS研究与新生儿代谢 筛查（NBS）计划数据，以识别和验证出生时测量的代谢谱， 二手电子烟和传统香烟的接触。我们建议的研究将解决 这将是一个重要的问题，并将具有重大的公共卫生意义。它将提供急需的信息 关于怀孕期间使用电子烟研究结果肯定会为政策提供信息，并推动公共卫生倡议， 有针对性的证据 母胎 戒烟和减轻吸烟对健康的不良影响 结果。它可以进一步提供解决最近爆发的电子烟，或vaping， 产品使用相关肺损伤（EVALI）。

PROJECT ABSTRACT Electronic cigarettes (e-cigarettes), since their first introduction in the world market in 2004, have been advertised as a healthier alternative and a smoking cessation aid to existing tobacco products. has youth E-cigarette use been increased dramatically in the recent years, becoming the most commonly used smoking product in and young adults since 2014. Itis particularly appealing to pregnant women smokers who are motivated to change their smoking habits and to improve their and their fetus' health. However, the potential adverse effects of e-cigarettes as shown in the recent outbreak, whether it poses an increased risk to women and their developing fetus, is unknown. The overarching objectives of the study are 1) to determine the longitudinal pattern of women's smoking from preconception to perinatal period and over time, 2) to determine the association between pregnancy e-cigarette use and pregnancy, perinatal, and infant related adverse outcomes, and 3) to determine the association between pregnancy e-cigarette use and metabolic profile measured at birth. We propose to conduct a surveillance study of women who gave live births between 2016- 2018 and participated in the Centers for Disease Control and Prevention (CDC) initiated Pregnancy Risk Assessment Monitoring System (PRAMS) survey. Detailed smoking information, including conventional cigarette and e-cigarette use during preconception, 3rd trimester of pregnancy, and post-delivery have been collected. We will further link PRAMS study of women from Tennessee and Iowa to newborn metabolic screening (NBS) program data to identify and validate metabolic profile measured at birth that are associated with secondhand in utero e-cigarette and conventional cigarette exposure. Our proposed study will address important questions and will be of significant public health importance. It will provide much needed information about pregnancy e-cigarette use. Results will certainly inform policy and drive public health initiative, providing evidence for targeted maternal-fetal interventions in smoking cessation and in mitigating adverse effects of smoking on outcomes. It may further provide insight in addressing recent outbreak of e-cigarette, or vaping, product use associated lung injury (EVALI).