Core E: Imaging Core

核心E：成像项目总结 该计划的成像核心项目赠款"健康老龄化和老年痴呆症"（HASD）将提供 磁共振成像（MRI）、淀粉样蛋白正电子发射断层扫描的定量成像结果 (PET)使用[11 C]-匹兹堡化合物B（PiB），和使用[18 F]-AV-1451（T807，flortaucipir）的tau PET， 支持附属项目和核心。定量MRI测量将包括体积MRI、定量MRI和定量MRI。 和血管病理学的定性评价，包括白色高信号（WMH）和脑 梗塞和微血管病变。淀粉样蛋白和tau PET将包括标准化的汇总统计量。 区域和整体负担的体素z分数分析以及随时间的变化。探索性措施将 继续包括静息状态功能连接MRI（rs-fcMRI）、弥散基础频谱成像 （DBSI）用于神经炎症，动脉自旋标记（ASL）用于血流，使用与 阿尔茨海默病神经影像学倡议（ADNI-3）和显性遗传阿尔茨海默病网络 （戴安娜）。我们将继续探索新的MRI和PET选择，因为这些成为可用的，如替代 与HASD项目和核心相关时，用于tau病理学或突触成像的PET示踪剂。我们将 我还将继续通过开放获取的更新版本促进HASD成像数据的共享 影像学研究系列（OASIS）项目。

Core E: Imaging Project Summary The Imaging Core of the Program Project Grant "Healthy Aging and Senile Dementia" (HASD) will provide quantitative imaging results for magnetic resonance imaging (MRI), amyloid positron emission tomography (PET) using [11C]-Pittsburgh Compound B (PiB), and tau PET using [18F]-AV-1451 (T807, flortaucipir) to support the affiliated Projects and Cores. Quantitative MRI measures will include volumetric MRI, quantitative and qualitative evaluations of vascular pathology including white matter hyperintensitites (WMH) and cerebral infarctions and microhemorrhages. Amyloid and tau PET will include summary statistics for standardized regions and voxelwise z-score analyses for overall burden and change over time. Exploratory measures will continue to include resting state functional connectivity MRI (rs-fcMRI), diffusion basis spectrum imaging (DBSI) for neuroinflammation, and arterial spin labelling (ASL) for blood flow using protocols compatible with the Alzheimer Disease Neuroimaging Initiative (ADNI-3) and the Dominantly Inherited Alzheimer Network (DIAN). We will continue to explore new MRI and PET options as these become available, such as alternative PET tracers for tau pathology or synaptic imaging, when relevant to the HASD Projects and Cores. We will also continue to promote sharing of the HASD imaging data through updated releases of the Open Access Series of Imaging Studies (OASIS) project.